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Jan Nilsson

Professor

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Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome

Author

  • S. Holm Nielsen
  • L. Jonasson
  • K. Kalogeropoulos
  • M. A. Karsdal
  • A. L. Reese-Petersen
  • U. auf dem Keller
  • F. Genovese
  • J. Nilsson
  • I. Goncalves

Summary, in English

Cardiovascular disease (CVD) is the most common cause of death in industrialized countries. One underlying cause is atherosclerosis, which is a systemic disease characterized by plaques of retained lipids, inflammatory cells, apoptotic cells, calcium and extracellular matrix (ECM) proteins in the arterial wall. The biologic composition of an atherosclerotic plaque determines whether the plaque is more or less vulnerable, that is prone to rupture or erosion. Here, the ECM and tissue repair play an important role in plaque stability, vulnerability and progression. This review will focus on ECM remodelling in atherosclerotic plaques, with focus on how ECM biomarkers might predict plaque vulnerability and outcome.

Department/s

  • Cardiovascular Research - Immunity and Atherosclerosis
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health
  • Cardiovascular Research - Translational Studies

Publishing year

2020-05

Language

English

Pages

493-513

Publication/Series

Journal of Internal Medicine

Volume

287

Issue

5

Document type

Journal article review

Publisher

Wiley-Blackwell

Topic

  • Cell and Molecular Biology

Keywords

  • atherosclerosis
  • biomarkers
  • extracellular matrix
  • outcome
  • vulnerable plaque

Status

Published

Research group

  • Cardiovascular Research - Immunity and Atherosclerosis
  • Cardiovascular Research - Translational Studies

ISBN/ISSN/Other

  • ISSN: 0954-6820