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Active and passive immunization for atherosclerosis

Author:
  • Kuang-Yuh Chyu
  • Jan Nilsson
  • Prediman K. Shah
Publishing year: 2007
Language: English
Pages: 176-182
Publication/Series: Current Opinion in Molecular Therapeutics
Volume: 9
Issue: 2
Document type: Journal article review
Publisher: Thomson Reuters

Abstract english

This review summarizes experimental findings that highlight the role of immune mechanisms in atherosclerosis and the potential atheroprotective effects of active or passive immunization strategies. Immunomodulation therapy appears to be feasible and effective, suggesting that a vaccine for atherosclerosis can be developed for clinical testing. Given the increasing number of patients with atherosclerotic disease on current therapy, a new therapy is needed and an immunization strategy could provide such a possibility. Several questions regarding this approach remain unanswered, however, such as choice of optimal antigens, choice of most effective adjuvants, the optimal route of administration, durability of effects and safety, but cautious optimism remains that a vaccine-based approach has the potential to become a part of the armamentarium for atherosclerotic vascular disease.

Keywords

  • Cardiac and Cardiovascular Systems
  • immunization
  • atherosclerosis
  • immune response
  • vaccination

Other

Published
  • Cardiovascular Research - Immunity and Athersosclerosis
  • ISSN: 2040-3445
E-mail: jan [dot] nilsson [at] med [dot] lu [dot] se

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