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Jan Nilsson

Professor

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Active and passive immunization for atherosclerosis

Author

  • Kuang-Yuh Chyu
  • Jan Nilsson
  • Prediman K. Shah

Summary, in English

This review summarizes experimental findings that highlight the role of immune mechanisms in atherosclerosis and the potential atheroprotective effects of active or passive immunization strategies. Immunomodulation therapy appears to be feasible and effective, suggesting that a vaccine for atherosclerosis can be developed for clinical testing. Given the increasing number of patients with atherosclerotic disease on current therapy, a new therapy is needed and an immunization strategy could provide such a possibility. Several questions regarding this approach remain unanswered, however, such as choice of optimal antigens, choice of most effective adjuvants, the optimal route of administration, durability of effects and safety, but cautious optimism remains that a vaccine-based approach has the potential to become a part of the armamentarium for atherosclerotic vascular disease.

Department/s

  • Cardiovascular Research - Immunity and Atherosclerosis

Publishing year

2007

Language

English

Pages

176-182

Publication/Series

Current Opinion in Molecular Therapeutics

Volume

9

Issue

2

Document type

Journal article review

Publisher

Thomson Reuters

Topic

  • Cardiac and Cardiovascular Systems

Keywords

  • immunization
  • atherosclerosis
  • immune response
  • vaccination

Status

Published

Research group

  • Cardiovascular Research - Immunity and Atherosclerosis

ISBN/ISSN/Other

  • ISSN: 2040-3445