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Jan Nilsson

Professor

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High levels of cathepsin D and cystatin B are associated with increased risk of coronary events.

Author

  • Isabel Goncalves
  • Karin Hultman
  • Pontus Dunér
  • Andreas Edsfeldt
  • Bo Hedblad
  • Gunilla Nordin Fredrikson
  • Harry Björkbacka
  • Jan Nilsson
  • Eva Bengtsson

Summary, in English

The majority of acute coronary syndromes are caused by plaque ruptures. Proteases secreted by macrophages play an important role in plaque ruptures by degrading extracellular matrix proteins in the fibrous cap. Matrix metalloproteinases have been shown to be markers for cardiovascular disease whereas the members of the cathepsin protease family are less studied.

Department/s

  • Cardiovascular Research - Immunity and Atherosclerosis
  • Cardiovascular Research - Epidemiology
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2016

Language

English

Pages

000353-000353

Publication/Series

Open Heart

Volume

3

Issue

1

Document type

Journal article

Publisher

BMJ Publishing Group

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Cardiovascular Research - Immunity and Atherosclerosis
  • Cardiovascular Research - Epidemiology

ISBN/ISSN/Other

  • ISSN: 2053-3624