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High levels of cathepsin D and cystatin B are associated with increased risk of coronary events.

  • Isabel Goncalves
  • Karin Hultman
  • Pontus Dunér
  • Andreas Edsfeldt
  • Bo Hedblad
  • Gunilla Nordin Fredrikson
  • Harry Björkbacka
  • Jan Nilsson
  • Eva Bengtsson
Publishing year: 2016
Language: English
Pages: 000353-000353
Publication/Series: Open Heart
Volume: 3
Issue: 1
Document type: Journal article
Publisher: BMJ Publishing Group

Abstract english

The majority of acute coronary syndromes are caused by plaque ruptures. Proteases secreted by macrophages play an important role in plaque ruptures by degrading extracellular matrix proteins in the fibrous cap. Matrix metalloproteinases have been shown to be markers for cardiovascular disease whereas the members of the cathepsin protease family are less studied.


  • Cardiac and Cardiovascular Systems


  • Cardiovascular Research - Immunity and Athersosclerosis
  • Cardiovascular Research - Epidemiology
  • ISSN: 2053-3624
E-mail: jan [dot] nilsson [at] med [dot] lu [dot] se

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