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Endarterectomy patients with elevated levels of circulating IL-16 have fewer cardiovascular events during follow-up

  • Caitríona Grönberg
  • Giuseppe Asciutto
  • Ana Persson
  • Gunilla Nordin Fredrikson
  • Jan Nilsson
  • Isabel Gonçalves
  • Harry Björkbacka
Publishing year: 2016-09
Language: English
Pages: 137-139
Publication/Series: Cytokine
Volume: 85
Document type: Journal article
Publisher: Academic Press

Abstract english

Background and purpose Increased interleukin 16 (IL-16) levels in carotid plaques have been associated with reduced incidence of cardiovascular (CV) events during follow-up in patients who underwent carotid endarterectomy (CEA). In the present study we aimed to determine whether high circulating levels of IL-16 also are associated with a decreased risk of CV events after CEA. Methods Patients, who had their carotid plaques surgically removed (n = 473), were followed for a mean follow-up time of 3.1 years. Plasma levels of IL-16 the day before surgery were analyzed by proximity extension assay (PEA) and associated with the occurrence of CV events during follow-up (n = 98). Results High levels of circulating IL-16 were independently associated with a decreased risk of CV events when comparing the highest versus the lowest IL-16 tertile (hazard ratio [HR] 0.47; 95% CI 0.27–0.81; P = 0.007), as well as with CV deaths (HR 0.25; 95% CI 0.09–0.70; P = 0.008). Conclusion These present findings indicate an association between IL-16 and less clinical complications of atherosclerosis in a population with known advanced carotid disease.


  • Cardiac and Cardiovascular Systems
  • Atherosclerosis
  • Cardiovascular events
  • Interleukin 16


  • Cardiovascular Research - Immunity and Athersosclerosis
  • ISSN: 1043-4666
E-mail: jan [dot] nilsson [at] med [dot] lu [dot] se

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