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Increased aldehyde-modification of collagen type IV in symptomatic plaques - A possible cause of endothelial dysfunction.

  • Pontus Dunér
  • Isabel Goncalves
  • Helena Grufman
  • Andreas Edsfeldt
  • Fong To
  • Mihaela Nitulescu
  • Jan Nilsson
  • Eva Bengtsson
Publishing year: 2015
Language: English
Pages: 26-32
Publication/Series: Atherosclerosis
Volume: 240
Issue: 1
Document type: Journal article
Publisher: Elsevier

Abstract english

Subendothelial LDL-adhesion and its subsequent oxidation are considered as key events in the development of atherosclerotic lesions. During oxidation of LDL, reactive aldehydes such as malondialdehyde (MDA) are formed, which modify apolipoprotein B100. However, the possibility that these reactive aldehydes could leak out of the LDL-particle and modify surrounding extracellular matrix proteins has been largely unexplored. We have investigated if aldehyde-modification of collagen type IV, one of the major basement membrane components, in plaques is associated with cardiovascular events.


  • Cardiac and Cardiovascular Systems


  • Cardiovascular Research - Immunity and Atherosclerosis
  • ISSN: 1879-1484
E-mail: jan [dot] nilsson [at] med [dot] lu [dot] se

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