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Jan Nilsson


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Carotid atherosclerosis, changes in tissue remodeling and repair in patients with aortic coarctation


  • Joanna Hlebowicz
  • Johan Holm
  • Sandra Lindstedt
  • Isabel Goncalves
  • Jan Nilsson

Summary, in English

Background and aims: After aortic coarctation (CoA) repair, patients still suffer from cardiovascular complications. The aim of this study was to measure cardiovascular markers, intima-media thickness (IMT) and plaques in controls and patients with CoA. Methods: Sixty-four patients with CoA (66% male, mean age 48 ± 15 years) and controls (54% men, mean age 47 ± 16 years) underwent ultrasound of their arteries. A multiplex platform to analyze circulating blood levels biomarkers reflecting inflammation, tissue remodeling and repair was used. Results: In men following CoA repair, a significantly increased carotid bulb IMT was observed in comparison to the control group (1.05 [0.72–1.24] vs. 0.67 [0.59–0.95] mm; p = 0.003). Median common carotid artery (CCA) IMT was increased in men compared to controls (0.82 [0.61–0.97] mm vs. 0.58 [0.53–0.76] mm, p < 0.003) and in women compared to controls (0.83 [0.70–0.92] vs. 0.60 [0.55–0.69], p < 0.004). CoA demonstrated an independent association with IMT in both men and women. Men with CoA were also more likely to have a plaque in their carotid arteries (p = 0.010). In women with CoA, we observed significantly lower levels of stem cell factor (SCF, p = 0.004) while in men with CoA we observed significantly lower levels of matrix metalloproteinase-3 (MMP-3, p = 0.048), tumor necrosis factor receptor 1 (TNF-R1, p = 0.032), tumor necrosis factor receptor superfamily member 10B (TRAIL-R2, p = 0.019) and monocyte chemotactic protein 1 (MCP-1, p = 0.015). Conclusions: This is the first study to show that despite successful CoA repair, patients have more carotid atherosclerosis than can be explained by changes in tissue remodeling and repair.


  • Cardiology
  • Clinical and experimental lung transplantation
  • DCD transplantation of lungs
  • NPWT technology
  • LUCC: Lund University Cancer Centre
  • StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • Cardiovascular Research - Translational Studies
  • EpiHealth: Epidemiology for Health
  • Cardiovascular Research - Immunity and Atherosclerosis

Publishing year










Document type

Journal article




  • Cardiac and Cardiovascular Systems


  • Aortic coarctation
  • Atherosclerosis
  • Biomarkers
  • Carotid atherosclerosis



Research group

  • Clinical and experimental lung transplantation
  • DCD transplantation of lungs
  • NPWT technology
  • Cardiovascular Research - Translational Studies
  • Cardiovascular Research - Immunity and Atherosclerosis


  • ISSN: 0021-9150