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Biomarkers of blood cadmium and incidence of cardiovascular events in non-smokers : Results from a population-based proteomics study

  • Yan Borné
  • Björn Fagerberg
  • Gerd Sallsten
  • Bo Hedblad
  • Margaretha Persson
  • Olle Melander
  • Jan Nilsson
  • Marju Orho-Melander
  • Lars Barregard
  • Gunnar Engström
Publishing year: 2019-05-15
Language: English
Publication/Series: Clinical Proteomics
Volume: 16
Issue: 1
Document type: Journal article
Publisher: Humana Press

Abstract english

Background: Cadmium is a toxic metal with multiple adverse health effects, including risk of cardiovascular disease (CVD). The mechanistic link between cadmium and CVD is unclear. Our aim was to examine the associations between blood cadmium (B-Cd) and 88 potential protein biomarkers of CVD. Methods: B-Cd and 88 plasma proteins were measured in a community-based prospective cohort, the Malmö Diet and Cancer study. The primary analysis was performed in never smokers (n = 1725). Multiple linear regression was used with adjustments for age and sex, and correction for multiple comparisons using the false discovery rate method. Proteins significantly associated with B-Cd were replicated in long-term former smokers (n = 782). Significant proteins were then studied in relation to incidence of CVD (i.e., coronary events or ischemic stroke) in never smokers. Results: Fifteen proteins were associated with B-Cd in never smokers. Eight of them were replicated in long-term former smokers. Kidney injury molecule-1, fibroblast growth factor-23 (FGF23), tumor necrosis factor receptor-2, matrix metalloproteinase-12, cathepsin L1, urokinase plasminogen activator receptor, C-C motif chemokine-3 (CCL3), and chemokine (C-X3-C motif) ligand-1 were associated with B-Cd both in never smokers and long-term former smokers. Except for CCL3 and FGF23, these proteins were also significantly associated with incidence of CVD. Conclusions: B-Cd in non-smokers was associated with eight potential plasma biomarkers of CVD and kidney injury. The results suggest pathways for the associations between B-Cd and CVD and kidney injury.


  • Cardiac and Cardiovascular Systems
  • Pharmacology and Toxicology
  • Cadmium
  • Cohort study
  • CVD
  • Non-smokers
  • Proteomics study


  • Cardiovascular Research - Epidemiology
  • Internal Medicine - Epidemiology
  • Cardiovascular Research - Hypertension
  • Cardiovascular Research - Immunity and Athersosclerosis
  • Diabetes - Cardiovascular Disease
  • ISSN: 1542-6416
E-mail: jan [dot] nilsson [at] med [dot] lu [dot] se

Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00