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Jan Nilsson

Professor

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Lymphocytes in atherosclerosis

Author

  • Maria Wigren
  • Jan Nilsson
  • Daniel Kolbus

Summary, in English

It is well established that atherosclerosis is caused by an inflammatory process in the arterial intima. However, it is only in recent years that it has become clear that this inflammation is modulated by immune responses against plaque antigens. These antigens are primarily believed to be modified self-antigens such as oxidized LDL. The immune system is challenged to determine whether these antigens should be regarded self and tolerated or non-self and eliminated. The latter will result in plaque development while the first will be protective. T cells are key effectors of both types of responses. An activation of regulatory T cells inhibits auto-reactive T effector cells and is anti-inflammatory. In contrast, if Th1 cells become activated in the plaque this is associated with increased inflammation and disease progression. The role of B cells in atherosclerosis remains to be clarified but some species of athero-protective antibodies have been identified. The elucidation of role of immune system in atherosclerosis has revealed new targets for intervention and both vaccines and antibody-based therapies are presently in or due to enter clinical testing. (c) 2012 Elsevier B.V. All rights reserved.

Department/s

  • Cardiovascular Research - Immunity and Atherosclerosis
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2012

Language

English

Pages

1562-1568

Publication/Series

Clinica Chimica Acta

Volume

413

Issue

19-20

Document type

Journal article review

Publisher

Elsevier

Topic

  • Clinical Laboratory Medicine

Keywords

  • Atherosclerosis
  • Adaptive immunity
  • Regulatory T cells
  • Th1 cells
  • Immune therapy

Status

Published

Research group

  • Cardiovascular Research - Immunity and Atherosclerosis

ISBN/ISSN/Other

  • ISSN: 0009-8981