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Jan Nilsson

Professor

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Vaccination against atherosclerosis? Induction of atheroprotective immunity

Author

  • Goran K. Hansson
  • Jan Nilsson

Summary, in English

Atherosclerosis involves the formation of inflammatory arterial lesions and is one of the most common causes of death globally. It has been evident for more than 20 years that adaptive immunity regulates the magnitude of the atherogenic proinflammatory response. T cells may also influence the stability of the atherosclerotic lesion and thus the propensity for thrombus formation and the clinical outcome of disease. Immunization of hypercholesterolemic animals with low-density lipoprotein preparations reduces atherosclerosis, suggesting that vaccination may represent a useful strategy for disease prevention or modulation. This review summarizes our current understanding of the role immunity in atherosclerosis and outlines strategies for antigen-specific prevention of this disease.

Department/s

  • Cardiovascular Research - Immunity and Atherosclerosis

Publishing year

2009

Language

English

Pages

95-101

Publication/Series

Seminars in Immunopathology

Volume

31

Issue

1

Document type

Journal article review

Publisher

Springer

Topic

  • Immunology in the medical area

Status

Published

Research group

  • Cardiovascular Research - Immunity and Atherosclerosis

ISBN/ISSN/Other

  • ISSN: 1863-2300