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Association between IgM against an aldehyde-modified peptide in apolipoprotein B-100 and progression of carotid disease

Author:
  • Gunilla Nordin Fredrikson
  • Bo Hedblad
  • Göran Berglund
  • Ragnar Alm
  • Jan-Åke Nilsson
  • Alexandru Schiopu
  • Prediman K Shah
  • Jan Nilsson
Publishing year: 2007
Language: English
Pages: 1495-1500
Publication/Series: Stroke: a journal of cerebral circulation
Volume: 38
Issue: 5
Document type: Journal article
Publisher: American Heart Association

Abstract english

Background and Purpose - Autoantibodies against antigens in oxidized low-density lipoprotein are common in people; experimental studies suggest that these immune responses have a functional role in the disease process. The aim of this study was to evaluate the relationship between the immune response against one defined oxidized low-density lipoprotein antigen, the aldehyde-modified peptide corresponding amino acids 3136 and 3155 (MDA-p210) in apolipoprotein (apo) B-100, and progression of carotid intima media thickness (IMT). Methods - IgM and IgG against MDA-p210 were determined by enzyme-linked immunosorbent assay at baseline and after 12 months of treatment with placebo, metoprolol, fluvastatin, or metoprolol/ fluvastatin in 751 individuals participating in the BCAPS. Carotid IMT was assessed by ultrasonography at baseline and after 18 and 36 months of treatment. Results - Antibody levels did not change in response to treatment, but high baseline MDA-p210 IgM levels were associated with a more rapid progression of carotid disease both at 18 ( r = 0.09, P < 0.05) and 36 months ( r = 0.12, P < 0.005). At 36 months, the difference in IMT progression rate per year between those with high MDA-p210 IgM levels and those with low was 0.011 mm ( 95% CI = 0.005 to 0.018 mm, P < 0.0001). Treatment with fluvastatin markedly decreased the progression of IMT among subjects with high but not with low MDA-p210 IgM levels. There was no association between MDA-p210 IgG and carotid IMT progression. Conclusions - IgM against the aldehyde-modified peptide corresponding amino acids 3136 and 3155 in apo B-100 is common in subjects with asymptomatic carotid disease, and high levels are associated with a more rapid progression of carotid IMT. The observation that the effect of fluvastatin was restricted to subjects with high MDA-p210 IgM levels may reflect the increased rate of disease progression in this group.

Keywords

  • Neurology
  • carotid arteries
  • atherosclerosis
  • echocardiography
  • lipoproteins
  • immune system

Other

Published
  • Cardiovascular Research - Immunity and Athersosclerosis
  • Cardiovascular Research - Epidemiology
  • Internal Medicine - Epidemiology
  • Orthopedics - Clinical and Molecular Osteoporosis Research
  • Joint and Soft Tissue Unit
  • ISSN: 1524-4628
E-mail: jan [dot] nilsson [at] med [dot] lu [dot] se

Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00