The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Jan Hedenbro

Jan Hedenbro

Visiting research fellow

Jan Hedenbro

Alcohol Consumption in Obese Patients Before and After Gastric Bypass as Assessed with the Alcohol Marker Phosphatidylethanol (PEth)

Author

  • Lisa Walther
  • Carl Magnus Brodén
  • Anders Isaksson
  • Jan L. Hedenbro

Summary, in English

Introduction: Roux-en-Y gastric bypass (RYGB) causes more rapid and enhanced absorption of alcohol. RYGB patients have also been reported to use more inpatient care for alcohol-related disease than do patients after other bariatric procedures. The present study was designed to evaluate alcohol consumption level before and after gastric bypass using a sensitive and specific alcohol biomarker. Materials and Methods: Two separate consecutive groups of patients and a group of healthy blood donors, as reference group, were included in the study. Alcohol intake was assessed using the alcohol marker phosphatidylethanol (PEth) at preoperative baseline and at 1 and 2 years postoperatively. In the first patient group (n = 133), neither surgeon nor patient was informed about the results of PEth testing. In the second group (n = 214), PEth results above 0.30 μmol/L were considered to indicate excessive alcohol consumption and led to preoperative alcohol counseling. The groups were followed for 2 and 1 year, respectively. Results: PEth results were significantly lower in both patient groups at baseline as well as postoperatively compared with the reference group. In both patient groups, there was a significant increase in PEth values at postoperative follow-up compared to baseline. Conclusions: Several physiological changes postoperatively have to be considered when interpreting PEth results in obese patients with dramatic weight reductions. According to results for PEth, obese patients treated with bariatric surgery would seem to have lower alcohol consumption compared with the reference group. Although slightly increasing their PEth values postoperatively, the RYGB patients did not reach the PEth values of the reference group.

Department/s

  • Division of Clinical Chemistry and Pharmacology
  • Surgery

Publishing year

2018-08

Language

English

Pages

2354-2360

Publication/Series

Obesity Surgery

Volume

28

Issue

8

Document type

Journal article

Publisher

Springer

Topic

  • Surgery
  • Nutrition and Dietetics

Keywords

  • Alcohol
  • Alcohol abuse
  • Alcohol marker
  • Gastric bypass
  • Phosphatidylethanol

Status

Published

Research group

  • Surgery

ISBN/ISSN/Other

  • ISSN: 0960-8923