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Jan Apelqvist


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Amputation-free survival in patients with diabetic foot ulcer and peripheral arterial disease : Endovascular versus open surgery in a propensity score adjusted analysis


  • Talha Butt
  • Erika Lilja
  • Targ Elgzyri
  • Jan Apelqvist
  • Anders Gottsäter
  • Gunnar Engström
  • Stefan Acosta

Summary, in English

Aims: The aim of the present study was to compare outcomes of endovascular surgery versus open vascular surgery in patients with diabetic foot ulcer (DFU) and peripheral arterial disease (PAD). Methods: Between 1984 and 2006, 1151 patients with DFU were admitted to the diabetic foot care team. Three hundred seventy-six patients with 408 limbs were consecutively included at a multidisciplinary foot center, 289 limbs were treated with endovascular surgery and 119 limbs with open vascular surgery first strategy. A propensity score adjusted analysis was performed to compare outcomes for type of revascularization. Results: Major amputation rates at 3 years were 17.0% and 16.8% (p = 0.97) and mortality at 3 years were 43.1% and 46.5% (p = 0.55) after endovascular surgery and open vascular surgery, respectively. In the propensity score adjusted analysis, patients undergoing endovascular surgery first had similar outcomes in terms of major amputation, mortality, combined major amputation/mortality compared to those undergoing open vascular surgery. Longer time to intervention (p = 0.003) was associated with increased major amputation rate in the multivariable Cox regression analysis. Conclusion: The endovascular surgery first and open vascular surgery first strategies were associated with similar long-term results in a large cohort of patients with DFU and PAD undergoing revascularization. Rapid revascularization reduces the risk of amputation.


  • Vascular Diseases - Clinical Research
  • Genomics, Diabetes and Endocrinology
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • Cardiovascular Research - Epidemiology
  • EpiHealth: Epidemiology for Health

Publishing year





Journal of Diabetes and its Complications





Document type

Journal article




  • Endocrinology and Diabetes
  • Surgery


  • Diabetic foot ulcer
  • Endovascular surgery
  • Open vascular surgery
  • Peripheral arterial disease
  • Propensity score adjusted analysis



Research group

  • Vascular Diseases - Clinical Research
  • Genomics, Diabetes and Endocrinology
  • Cardiovascular Research - Epidemiology


  • ISSN: 1056-8727