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Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials.

Author:
  • Jessica L Mega
  • Nathan O Stitziel
  • Gustav Smith
  • Daniel I Chasman
  • Mark J Caulfield
  • James J Devlin
  • Francesco Nordio
  • Craig L Hyde
  • Christopher P Cannon
  • Frank M Sacks
  • Neil R Poulter
  • Peter S Sever
  • Paul M Ridker
  • Eugene Braunwald
  • Olle Melander
  • Sekar Kathiresan
  • Marc S Sabatine
Publishing year: 2015
Language: English
Pages: 2264-2271
Publication/Series: The Lancet
Volume: 385
Issue: 9984
Document type: Journal article
Publisher: Elsevier Limited

Abstract english

Genetic variants have been associated with the risk of coronary heart disease. In this study, we tested whether or not a composite of these variants could ascertain the risk of both incident and recurrent coronary heart disease events and identify those individuals who derive greater clinical benefit from statin therapy.

Keywords

  • Cardiac and Cardiovascular Systems

Other

Published
  • Hypertension and Cardiovascular Disease
  • ISSN: 1474-547X
E-mail: gustav [dot] smith [at] med [dot] lu [dot] se

Associate professor

Cardiology

+46 46 17 26 33

D1232C

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Research project participant

Cardiovascular Epigenetics

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Research project participant

Heart Failure and Mechanical Support

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Project manager

Molecular Epidemiology and Cardiology

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