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Lp-PLA2 activity and mass for prediction of incident abdominal aortic aneurysms : A prospective longitudinal cohort study

Author:
  • Stefan Acosta
  • Soumia Taimour
  • Anders Gottsäter
  • Margaretha Persson
  • Gunnar Engström
  • Olle Melander
  • Moncef Zarrouk
  • Peter M. Nilsson
  • J. Gustav Smith
Publishing year: 2017-07-01
Language: English
Pages: 14-18
Publication/Series: Atherosclerosis
Volume: 262
Document type: Journal article
Publisher: Elsevier

Abstract english

Background and aims The pathogenesis of abdominal aortic aneurysm (AAA) shares several common pathways with atherosclerosis. Prospective clinical plasma biomarker studies in AAA have been hampered by the need for very large cohorts and long follow-up time. Methods We analyzed a prospective longitudinal cohort of middle-aged individuals from the cardiovascular cohort of the Malmö Diet and Cancer study (n = 5551; 1991-94). The plasma biomarkers lipoprotein-associated phospholipase A2 (Lp-PLA2 activity and mass), proneurotensin and C-reactive protein, and conventional risk factors at baseline were measured in patients with incident AAA during follow-up, and compared to individuals without a diagnosis of AAA. Subjects were followed until December 31st, 2013. Multivariable analyses were expressed in terms of hazard ratios (HR) per 1 standard deviation increment of each respective log-transformed plasma biomarker in the Cox proportional hazard models. Results Cumulative incidence of AAA was 1.5% (men 2.9%, women 0.5%) during a median follow-up period of 20.7 years. Overall, 84 individuals had an incident AAA, of whom 22 (26.2%) were operated on and 16 (19.0%) had ruptured. Mean age of individuals with incident AAA was 59.7 years at study entry and AAA was diagnosed on average 14 years later. When adjusting for age, gender, smoking, body mass index, hypertension, and diabetes mellitus, Lp-PLA2 activity (HR 1.40; 95% CI 1.15–1.72) and Lp-PLA2 mass (HR 1.23; 95% CI 1.00–1.51) were independently associated with incident AAA. Conclusions The plasma biomarkers Lp-PLA2 activity and mass were markers of AAA risk and this implies that AAA is an athero-thrombotic related disease.

Keywords

  • Cardiac and Cardiovascular Systems
  • Abdominal aortic aneurysm
  • Epidemiology
  • Incident AAA
  • Lipoprotein-associated phospholipase
  • Plasma biomarker

Other

Published
  • Clinical Vascular Disease Research
  • Internal Medicine
  • Cardio-vascular Epidemiology
  • Hypertension and Cardiovascular Disease
  • Cardiovascular Epigenetics
  • Molecular Epidemiology and Cardiology
  • Heart Failure and Mechanical Support
  • ISSN: 0021-9150
E-mail: gustav [dot] smith [at] med [dot] lu [dot] se

Associate professor

Cardiology

+46 46 17 26 33

D1232C

32

Research project participant

Cardiovascular Epigenetics

32

Research project participant

Heart Failure and Mechanical Support

32

Project manager

Molecular Epidemiology and Cardiology

+46 46 17 26 33

32

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