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Genetic Variant on Chromosome 12p13 Does Not Show Association to Ischemic Stroke in 3 Swedish Case-Control Studies

Author:
  • Sandra Olsson
  • Olle Melander
  • Katarina Jood
  • Gustav Smith
  • Håkan Lövkvist
  • Marketa Sjögren
  • Gunnar Engström
  • Bo Norrving
  • Arne Lindgren
  • Christina Jern
Publishing year: 2011
Language: English
Pages: 214-216
Publication/Series: Stroke: a journal of cerebral circulation
Volume: 42
Issue: 1
Document type: Journal article
Publisher: American Heart Association

Abstract english

Background and Purpose-In a genome-wide association study and subsequent case-control studies, the single-nucleotide polymorphism rs12425791 on chromosome 12p13 was reported to be associated with ischemic stroke, but this could not be validated in a recent well-powered study. We therefore investigated whether an association between ischemic stroke and rs12425791 could be detected in 3 different case-control studies from the southwest of Sweden. Methods-We examined 3606 patients with ischemic stroke and 2528 controls from 3 independent case-controls studies. Results-No significant association between ischemic stroke and the single-nucleotide polymorphism rs12425791 was detected in any of the 3 case-control samples or in the samples combined. The odds ratio for ischemic stroke for the minor allele in the combined sample was 1.02 (95% CI, 0.93 to 1.13). Conclusions-The single-nucleotide polymorphism rs12425791 does not confer a substantial risk for ischemic stroke in our population. Our results support a recent large study including other European populations. (Stroke. 2011;42:214-216.)

Keywords

  • Neurology
  • stroke
  • single-nucleotide polymorphism
  • genetic association studies

Other

Published
  • Hypertension and Cardiovascular Disease
  • Cardio-vascular Epidemiology
  • ISSN: 1524-4628
E-mail: gustav [dot] smith [at] med [dot] lu [dot] se

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