Lund University is celebrating 350 years.


Javascript is not activated in your browser. This website needs javascript activated to work properly.

Genetic Variant on Chromosome 12p13 Does Not Show Association to Ischemic Stroke in 3 Swedish Case-Control Studies

  • Sandra Olsson
  • Olle Melander
  • Katarina Jood
  • Gustav Smith
  • Håkan Lövkvist
  • Marketa Sjögren
  • Gunnar Engström
  • Bo Norrving
  • Arne Lindgren
  • Christina Jern
Publishing year: 2011
Language: English
Pages: 214-216
Publication/Series: Stroke: a journal of cerebral circulation
Volume: 42
Issue: 1
Document type: Journal article
Publisher: American Heart Association

Abstract english

Background and Purpose-In a genome-wide association study and subsequent case-control studies, the single-nucleotide polymorphism rs12425791 on chromosome 12p13 was reported to be associated with ischemic stroke, but this could not be validated in a recent well-powered study. We therefore investigated whether an association between ischemic stroke and rs12425791 could be detected in 3 different case-control studies from the southwest of Sweden. Methods-We examined 3606 patients with ischemic stroke and 2528 controls from 3 independent case-controls studies. Results-No significant association between ischemic stroke and the single-nucleotide polymorphism rs12425791 was detected in any of the 3 case-control samples or in the samples combined. The odds ratio for ischemic stroke for the minor allele in the combined sample was 1.02 (95% CI, 0.93 to 1.13). Conclusions-The single-nucleotide polymorphism rs12425791 does not confer a substantial risk for ischemic stroke in our population. Our results support a recent large study including other European populations. (Stroke. 2011;42:214-216.)


  • Neurology
  • stroke
  • single-nucleotide polymorphism
  • genetic association studies


  • Hypertension and Cardiovascular Disease
  • Cardio-vascular Epidemiology
  • ISSN: 1524-4628
E-mail: gustav [dot] smith [at] med [dot] lu [dot] se

Associate professor


+46 46 17 26 33



Research project participant

Cardiovascular Epigenetics


Research project participant

Heart Failure and Mechanical Support


Project manager

Molecular Epidemiology and Cardiology

+46 46 17 26 33


Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00