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Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation : The AFGen Consortium

  • Faye L Norby
  • Samuel Adamsson Eryd
  • Maartje N Niemeijer
  • Lynda M Rose
  • Albert V Smith
  • Xiaoyan Yin
  • Sunil K Agarwal
  • Dan E Arking
  • Daniel L Chasman
  • Lin Y Chen
  • Mark Eijgelsheim
  • Gunnar Engström
  • Oscar H Franco
  • Jan Heeringa
  • George Hindy
  • Albert Hofman
  • Pamela L Lutsey
  • Jared W Magnani
  • David D McManus
  • Marju Orho-Melander
  • James S Pankow
  • Gull Rukh
  • Christina-Alexandra Schulz
  • André G Uitterlinden
  • Christine M Albert
  • Emelia J Benjamin
  • Vilmundur Gudnason
  • Gustav Smith
  • Bruno H C Stricker
  • Alvaro Alonso
Publishing year: 2016
Language: English
Publication/Series: PLoS ONE
Volume: 11
Issue: 3
Document type: Journal article
Publisher: Public Library of Science

Abstract english

BACKGROUND: Several studies have shown associations between blood lipid levels and the risk of atrial fibrillation (AF). To test the potential effect of blood lipids with AF risk, we assessed whether previously developed lipid gene scores, used as instrumental variables, are associated with the incidence of AF in 7 large cohorts.

METHODS: We analyzed 64,901 individuals of European ancestry without previous AF at baseline and with lipid gene scores. Lipid-specific gene scores, based on loci significantly associated with lipid levels, were calculated. Additionally, non-pleiotropic gene scores for high-density lipoprotein cholesterol (HDLc) and low-density lipoprotein cholesterol (LDLc) were calculated using SNPs that were only associated with the specific lipid fraction. Cox models were used to estimate the hazard ratio (HR) and 95% confidence intervals (CI) of AF per 1-standard deviation (SD) increase of each lipid gene score.

RESULTS: During a mean follow-up of 12.0 years, 5434 (8.4%) incident AF cases were identified. After meta-analysis, the HDLc, LDLc, total cholesterol, and triglyceride gene scores were not associated with incidence of AF. Multivariable-adjusted HR (95% CI) were 1.01 (0.98-1.03); 0.98 (0.96-1.01); 0.98 (0.95-1.02); 0.99 (0.97-1.02), respectively. Similarly, non-pleiotropic HDLc and LDLc gene scores showed no association with incident AF: HR (95% CI) = 1.00 (0.97-1.03); 1.01 (0.99-1.04).

CONCLUSIONS: In this large cohort study of individuals of European ancestry, gene scores for lipid fractions were not associated with incident AF.


  • Clinical Medicine


  • ISSN: 1932-6203
E-mail: gustav [dot] smith [at] med [dot] lu [dot] se

Associate professor


+46 46 17 26 33



Research project participant

Cardiovascular Epigenetics


Research project participant

Heart Failure and Mechanical Support


Project manager

Molecular Epidemiology and Cardiology

+46 46 17 26 33


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