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ludc webb

Isabel Goncalves

Professor

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Reservoir Pressure Integral Is Independently Associated With the Reduction in Renal Function in Older Adults

Author

  • Kunihiko Aizawa
  • Alun D. Hughes
  • Francesco Casanova
  • Phillip E. Gates
  • David M. Mawson
  • Kim M. Gooding
  • Mark Gilchrist
  • Isabel Goncalves
  • Jan Nilsson
  • Faisel Khan
  • Helen M. Colhoun
  • Carlo Palombo
  • Kim H. Parker
  • Angela C. Shore

Summary, in English

Background: Arterial hemodynamic parameters derived from reservoir-excess pressure analysis exhibit prognostic utility. Reservoir-excess pressure analysis may provide useful information about an influence of altered hemodynamics on target organ such as the kidneys. We determined whether the parameters derived from the reservoir-excess pressure analysis were associated with the reduction in estimated glomerular filtration rate in 542 older adults (69.4±7.9 years, 194 females) at baseline and after 3 years. Methods: Reservoir-excess pressure parameters, including reservoir pressure integral, excess pressure integral, systolic, and diastolic rate constants, were obtained by radial artery tonometry. Results: After 3 years, and in a group of 94 individuals (72.4±7.6 years, 26 females), there was an estimated glomerular filtration rate reduction of >5% per year (median reduction of 20.5% over 3 years). A multivariable logistic regression analysis revealed that higher baseline reservoir pressure integral was independently associated with a smaller reduction in estimated glomerular filtration rate after accounting for conventional cardiovascular risk factors and study centers (odds ratio: 0.660 [95% CIs, 0.494-0.883]; P=0.005). The association remained unchanged after further adjustments for potential confounders and baseline renal function (odds ratio: 0.528 [95% CIs, 0.351-0.794]; P=0.002). No other reservoir-excess pressure parameters exhibited associations with the reduction in renal function. Conclusions: This study demonstrates that baseline reservoir pressure integral was associated with the decline in renal function in older adults at 3-year follow-up, independently of conventional cardiovascular risk factors. This suggests that reservoir pressure integral may play a role in the functional decline of the kidneys.

Department/s

  • EpiHealth: Epidemiology for Health
  • Cardiovascular Research - Translational Studies
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • Hepato-Pancreato-Biliary Surgery
  • Surgery (Lund)

Publishing year

2022-10-01

Language

English

Pages

2364-2372

Publication/Series

Hypertension

Volume

79

Issue

10

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Cardiac and Cardiovascular Systems

Keywords

  • Aging
  • Blood pressure
  • Hemodynamics
  • Kidney
  • Risk factors

Status

Published

Research group

  • Cardiovascular Research - Translational Studies
  • Hepato-Pancreato-Biliary Surgery

ISBN/ISSN/Other

  • ISSN: 0194-911X