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Isabel Goncalves

Professor

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Attenuation of Experimental Atherosclerosis by Interleukin-19.

Author

  • Stephen Ellison
  • Khatuna Gabunia
  • Sheri E Kelemen
  • Ross N England
  • Rosario Scalia
  • James M Richards
  • Wayne Orr
  • James G Traylor
  • Thomas Rogers
  • William Cornwell
  • Lisa Berglund
  • Isabel Goncalves
  • Maria Gomez
  • Michael V Autieri
Show all

Summary, in English

Interleukin-19 (IL-19) is a putative Th2, anti-inflammatory interleukin. Its expression and potential role in atherogenesis are unknown. IL-19 is not detected in normal artery and is expressed to a greater degree in plaque from symptomatic versus asymptomatic patients, suggesting a compensatory counter-regulatory function. We tested whether IL-19 could reduce atherosclerosis in susceptible mice and identified plausible mechanisms.

Department/s

  • EXODIAB: Excellence of Diabetes Research in Sweden
  • Cardiovascular Research - Immunity and Atherosclerosis
  • Cardiovascular Research - Translational Studies

Publishing year

2013

Language

English

Pages

2316-2324

Publication/Series

Arteriosclerosis, Thrombosis and Vascular Biology

Volume

33

Issue

10

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Cardiovascular Research - Immunity and Atherosclerosis
  • Cardiovascular Research - Translational Studies

ISBN/ISSN/Other

  • ISSN: 1524-4636