Isabel Goncalves

Increased proteolytic cleavage of osteoglycin is associated with a stable plaque phenotype and lower risk of cardiovascular events

Dania Al-Sharify, Signe Holm Nielsen, Frank Matthes, Christoffer Tengryd, Jiangming Sun, et al.
(2022) Atherosclerosis, 355 p.8-14
Journal article

Dynamic epigenetic age mosaicism in the human atherosclerotic artery

Silvio Zaina, Manel Esteller, Isabel Gonçalves, Gertrud Lund
(2022) PLoS ONE, 17
Journal article

Osteomodulin Gene Expression Is Associated with Plaque Calcification, Stability, and Fewer Cardiovascular Events in the CPIP Cohort

Isabel Gonçalves, Loureen Oduor, Frank Matthes, Narjess Rakem, Jakob Meryn, et al.
(2022) Stroke, 53 p.79-84
Journal article

Skin autofluorescence, a measure of tissue accumulation of advanced glycation end products, is associated with subclinical atherosclerosis in coronary and carotid arteries

Jingxue Pan, Xue Bao, Isabel Gonçalves, Amra Jujić, Gunnar Engström
(2022) Atherosclerosis, 345 p.26-32
Journal article

High levels of autoantibodies against apoB100 p210 are associated with lower incidence of atrial fibrillation in women

Kari Anne Sveen, Gustav Smith, Harry Björkbacka, Marju Orho-Melander, Gunnar Engström, et al.
(2022) Journal of Internal Medicine, 291 p.207-217
Journal article

Soluble CD40 receptor is a biomarker of the burden of carotid artery atherosclerosis in subjects at high cardiovascular risk

Simone Leonetti, Domenico Tricò, Lorenzo Nesti, Simona Baldi, Michaela Kozakova, et al.
(2022) Atherosclerosis, 343 p.1-9
Journal article

Associations of Red Cell Distribution Width With Coronary Artery Calcium in the General Population

Jingxue Pan, Yan Borné, Isabel Gonçalves, Margaretha Persson, Gunnar Engström
(2022) Angiology, 73 p.445-452
Journal article

Cardiovagal Function Measured by the Deep Breathing Test : Relationships With Coronary Atherosclerosis

Gunnar Engström, Viktor Hamrefors, Artur Fedorowski, Anders Persson, Maria E Johansson, et al.
(2022) Journal of the American Heart Association, 11 p.1-10
Journal article

Sub-micrometer morphology of human atherosclerotic plaque revealed by synchrotron radiation-based μCT—A comparison with histology

My Truong, Till Dreier, Johan Wasselius, Lena Sundius, Ana Persson, et al.
(2022) PLoS ONE, 17 p.1-18
Journal article

Osteomodulin attenuates smooth muscle cell osteogenic transition in vascular calcification

Nikolaos T Skenteris, Till Seime, Anna Witasp, Eva Karlöf, Grzegorz B Wasilewski, et al.
(2022) Clinical and Translational Medicine, 12 p.1-22
Journal article

Interferon regulatory factor-5-dependent CD11c+ macrophages contribute to the formation of rupture-prone atherosclerotic plaques

Andreas Edsfeldt, Maarten Swart, Pratibha Singh, Lea Dib, Jiangming Sun, et al.
(2022) European Heart Journal, 43 p.1864-1877
Journal article

Silencing of STE20-type kinase STK25 in human aortic endothelial and smooth muscle cells is atheroprotective

Emmelie Cansby, Sima Kumari, Mara Caputo, Ying Xia, Rando Porosk, et al.
(2022) Communications Biology, 5 p.1-14
Journal article

Circulating Hepatocyte Growth Factor Reflects Activation of Vascular Repair in Response to Stress

Yihong Chen, Junyan Shen, Anna Hultgårdh Nilsson, Isabel Goncalves, Andreas Edsfeldt, et al.
(2022) JACC: Basic to Translational Science
Journal article

Could targeting the macrophage urokinase-type plasminogen activator receptor be a bullseye for PET imaging of atherosclerotic plaque inflammation?

Jason M. Tarkin, Isabel Gonçalves
(2022) Atherosclerosis, 352 p.80-82
Journal article (comment)

Epigenome-Wide Histone Acetylation Changes in Peripheral Blood Mononuclear Cells in Patients with Type 2 Diabetes and Atherosclerotic Disease

Pradeep Bompada, Isabel Goncalves, Chuanyan Wu, Rui Gao, Jiangming Sun, et al.
(2021) Biomedicines, 9
Journal article

The potential role of T2*-weighted multi-echo data image combination as an imaging marker for intraplaque hemorrhage in carotid plaque imaging

My Truong, Claes Håkansson, Makda HaileMichael, Jonas Svensson, Jimmy Lätt, et al.
(2021) BMC Medical Imaging, 21
Journal article

Diverse ultrastructural landscape of atherosclerotic endothelium

Ewelina Kluza, Thijs J. Beldman, Annelie Shami, Edwin R. Scholl, Tsveta S. Malinova, et al.
(2021) Atherosclerosis, 339 p.35-45
Journal article

Carotid atherosclerosis, changes in tissue remodeling and repair in patients with aortic coarctation

Joanna Hlebowicz, Johan Holm, Sandra Lindstedt, Isabel Goncalves, Jan Nilsson
(2021) Atherosclerosis, 335 p.47-52
Journal article

Extracellular matrix: paving the way to the newest trends in atherosclerosis

Chrysostomi Gialeli, Annelie Shami, Isabel Gonçalves
(2021) Current Opinion in Lipidology, 32 p.277-285
Journal article

Prevalence of Subclinical Coronary Artery Atherosclerosis in the General Population

Göran Bergström, Margaretha Persson, Martin Adiels, Elias Björnson, Carl Bonander, et al.
(2021) Circulation, 144 p.916-929
Journal article

Soluble CD40 levels in plasma are associated with cardiovascular disease and in carotid plaques with a vulnerable phenotype

Annelie Shami, Andreas Edsfeldt, Eva Bengtsson, Jan Nilsson, Angela C. Shore, et al.
(2021) Journal of Stroke, 23 p.367-376
Journal article

Plaque vulnerability index predicts cardiovascular events : A histological study of an endarterectomy cohort

Isabel Goncalves, Jiangming Sun, Christoffer Tengryd, Mihaela Nitulescu, Ana F. Persson, et al.
(2021) Journal of the American Heart Association, 10
Journal article

Material Decomposition in Low-Energy Micro-CT Using a Dual-Threshold Photon Counting X-Ray Detector

Rasmus Solem, Till Dreier, Isabel Gonçalves, Martin Bech
(2021) Frontiers in Physics, 9
Journal article

The novel collagen matrikine, endotrophin, is associated with mortality and cardiovascular events in patients with atherosclerosis

S. Holm Nielsen, A. Edsfeldt, C. Tengryd, H. Gustafsson, A. C. Shore, et al.
(2021) Journal of Internal Medicine
Journal article

Glucocorticoid induced TNF receptor family-related protein (GITR) – A novel driver of atherosclerosis

Laura A. Bosmans, Annelie Shami, Dorothee Atzler, Christian Weber, Isabel Gonçalves, et al.
(2021) Vascular Pharmacology, 139
Journal article review

Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease

Michael Lacy, Christina Bürger, Annelie Shami, Maiwand Ahmadsei, Holger Winkels, et al.
(2021) Nature Communications, 12
Journal article

Classifications of atherosclerotic plaque components with T1 and T2* mapping in 11.7 T MRI

My Truong, Finn Lennartsson, Adnan Bibic, Lena Sundius, Ana Persson, et al.
(2021) European Journal of Radiology Open, 8 p.100323-100323
Journal article

Human Atherosclerotic Plaque Progression Is Dependent on Apoptosis According to Bomb-Pulse 14C Dating

Andreas Edsfeldt, Kristina Eriksson Stenström, Jiangming Sun, Nuno Dias, Göran Skog, et al.
(2021) JACC: Basic to Translational Science, 6 p.734-745
Journal article

The proteoglycan mimecan is associated with carotid plaque vulnerability and increased risk of future cardiovascular death

Christoffer Tengryd, Signe Holm Nielsen, Michele Cavalera, Eva Bengtsson, Federica Genovese, et al.
(2020) Atherosclerosis, 313 p.88-95
Journal article

The conundrum of asymptomatic carotid stenosis-determinants of decision and evidence

José Fernandes E Fernandes, Luis Mendes Pedro, Isabel Gonçalves
(2020) Annals of Translational Medicine, 8
Journal article review

Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome

S. Holm Nielsen, L. Jonasson, K. Kalogeropoulos, M. A. Karsdal, A. L. Reese-Petersen, et al.
(2020) Journal of Internal Medicine, 287 p.493-513
Journal article review

Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages

Ngoc Nguyen Lunde, Ida Gregersen, Thor Ueland, Christian Shetelig, Sverre Holm, et al.
(2020) Atherosclerosis, 296 p.74-82
Journal article

Low Levels of CD4+CD28null T Cells at Baseline Are Associated With First-Time Coronary Events in a Prospective Population-Based Case-Control Cohort

Lukas Tomas, Eva Bengtsson, Linda Andersson, Wiaam Badn, Christoffer Tengryd, et al.
(2020) Arteriosclerosis, Thrombosis, and Vascular Biology, 40 p.426-436
Journal article

Serology assessment of antibody response to SARS-CoV-2 in patients with COVID-19 by rapid IgM/IgG antibody test

Yang De Marinis, Torgny Sunnerhagen, Pradeep Bompada, Anna Bläckberg, Runtao Yang, et al.
(2020) Infection Ecology and Epidemiology, 10
Journal article

Evidence for a protective role of placental growth factor in cardiovascular disease

Yihong Chen, Anna Hultgårdh Nilsson, Isabel Goncalves, Andreas Edsfeldt, Gunnar Engström, et al.
(2020) Science Translational Medicine, 12
Journal article

Carotid Plaque Morphology is Similar in Patients with Reduced and Normal Renal Function

Caroline Heijl, Fredrik Kahn, Andreas Edsfeldt, Christoffer Tengryd, Jan Nilsson, et al.
(2020) Clinical Medicine Insights: Cardiology, 14
Journal article

Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans

Annelie Shami, Dorothee Atzler, Laura A. Bosmans, Holger Winkels, Svenja Meiler, et al.
(2020) European Heart Journal, 41 p.2938-2948
Journal article

Reduced oxidized LDL in T2D plaques is associated with a greater statin usage but not with future cardiovascular events

Pratibha Singh, Isabel Goncalves, Christoffer Tengryd, Mihaela Nitulescu, Ana F. Persson, et al.
(2020) Cardiovascular Diabetology, 19
Journal article

CD163+ macrophages are associated with a vulnerable plaque phenotype in human carotid plaques

Eva Bengtsson, Karin Hultman, Andreas Edsfeldt, Ana Persson, Mihaela Nitulescu, et al.
(2020) Scientific Reports, 10
Journal article

S100A9 Links Inflammation and Repair in Myocardial Infarction

Goran Marinković, Duco Steven Koenis, Lisa de Camp, Robert Jablonowski, Naomi Graber, et al.
(2020) Circulation Research, 127 p.664-676
Journal article

Elevated IL-27 in patients with acute coronary syndrome is associated with adverse ventricular remodeling and increased risk of recurrent myocardial infarction and cardiovascular death

Helena Grufman, Troels Yndigegn, Isabel Gonçalves, Jan Nilsson, Alexandru Schiopu
(2019) Cytokine, 122
Journal article

Cardiovascular organ damage in type 2 diabetes mellitus : The role of lipids and inflammation

Michaela Kozakova, Carmela Morizzo, Isabel Goncalves, Andrea Natali, Jan Nilsson, et al.
(2019) Cardiovascular Diabetology, 18
Journal article

Soluble TRAIL-R2 a marker of plaque cell apoptosis and cardiovascular events.

Isabel Goncalves, Pratibha Singh, Christoffer Tengryd, Michele Cavalera, Ingrid Yao Mattisson, et al.
(2019) Stroke: a journal of cerebral circulation, 50 p.1989-1996
Journal article

Activation of immune responses against the basement membrane component collagen type IV does not affect the development of atherosclerosis in ApoE-deficient mice

J. Vallejo, P. Dunér, F. To, D. Engelbertsen, I. Gonçalves, et al.
(2019) Scientific Reports, 9
Journal article

High Levels of Soluble Lectinlike Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Carotid Plaque Inflammation and Increased Risk of Ischemic Stroke

Hanna Markstad, Andreas Edsfeldt, Ingrid Yao Mattison, Eva Bengtsson, Pratibha Singh, et al.
(2019) Journal of the American Heart Association, 8
Journal article

Metformin is the key factor in elevated plasma growth differentiation factor-15 levels in type 2 diabetes : A nested, case–control study

Andrea Natali, Lorenzo Nesti, Elena Venturi, Angela C. Shore, Faisel Khan, et al.
(2019) Diabetes, Obesity and Metabolism, 21 p.412-416
Journal article

A biomarker of collagen type I degradation is associated with cardiovascular events and mortality in patients with atherosclerosis

S. Holm Nielsen, C. Tengryd, A. Edsfeldt, S. Brix, F. Genovese, et al.
(2019) Journal of Internal Medicine, 285 p.118-123
Journal article

Subclinical atherosclerosis and its progression are modulated by PLIN2 through a feed-forward loop between LXR and autophagy

P. Saliba-Gustafsson, M. Pedrelli, K. Gertow, O. Werngren, V. Janas, et al.
(2019) Journal of Internal Medicine, 286 p.660-675
Journal article

Cartilage Oligomeric Matrix Protein Associates With a Vulnerable Plaque Phenotype in Human Atherosclerotic Plaques

Karin Hultman, Andreas Edsfeldt, Harry Björkbacka, Pontus Dunér, Lena Sundius, et al.
(2019) Stroke, 50 p.3289-3292
Journal article

Transthyretin expression in the postischemic brain

Daniela Talhada, Isabel Gonçalves, Cecília Reis Santos, Karsten Ruscher
(2019) PLoS ONE, 14
Journal article

The soluble receptor for advanced glycation end-products (sRAGE) has a dual phase-dependent association with residual cardiovascular risk after an acute coronary event.

Helena Grauen Larsen, Troels Yndigegn, Goran Marinkovic, Anna Helena Maria Grufman, Razvan Mares, et al.
(2019) Atherosclerosis, 287 p.16-23
Journal article

Inhibition of pro-inflammatory myeloid cell responses by short-term S100A9 blockade improves cardiac function after myocardial infarction

Goran Marinković, Helena Grauen Larsen, Troels Yndigegn, Istvan Adorjan Szabo, Razvan Gheorghita Mares, et al.
(2019) European Heart Journal, 40 p.2713-2723
Journal article

Use of Vascular Assessments and Novel Biomarkers to Predict Cardiovascular Events in Type 2 Diabetes : The SUMMIT VIP Study

Angela C Shore, Helen M Colhoun, Andrea Natali, Carlo Palombo, Faisel Khan, et al.
(2018) Diabetes Care, 41 p.2212-2219
Journal article

Distinctive peri-luminal presence of agrin in murine and human carotid atherosclerotic plaques

Uwe Rauch, Eva Bengtsson, Isabel Gonçalves, Anna Hultgårdh-Nilsson
(2018) Histology and Histopathology, 33 p.717-726
Journal article

Altered metabolism distinguishes high-risk from stable carotid atherosclerotic plaques

Lukas Tomas, Andreas Edsfeldt, Inês G Mollet, Ljubica Perisic Matic, Cornelia Prehn, et al.
(2018) European Heart Journal, 39 p.2301-2310
Journal article

Spotty Carotid Plaques Are Associated with Inflammation and the Occurrence of Cerebrovascular Symptoms

Sanela Halak, Gerd Östling, Andreas Edsfeldt, Cecilia Kennbäck, Magnus Dencker, et al.
(2018) Cerebrovascular Diseases Extra, 8 p.16-25
Journal article

Markers of basement membrane remodeling are associated with higher mortality in patients with known atherosclerosis

Signe Holm Nielsen, Christoffer Tengryd, Andreas Edsfeldt, Susanne Brix, Federica Genovese, et al.
(2018) Journal of the American Heart Association, 7
Journal article

ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis

Eva Bengtsson, Karin Hultman, Pontus Dunér, Giuseppe Asciutto, Peter Almgren, et al.
(2017) Scientific Reports, 7
Journal article

Elevated Markers of Death Receptor-Activated Apoptosis are Associated with Increased Risk for Development of Diabetes and Cardiovascular Disease

Ingrid Yao Mattisson, Harry Björkbacka, Maria Wigren, Andreas Edsfeldt, Olle Melander, et al.
(2017) EBioMedicine, 26 p.187-197
Journal article

Plasma stem cell factor levels are associated with risk of cardiovascular disease and death

H Björkbacka, I Yao Mattisson, M Wigren, O Melander, G. N. Fredrikson, et al.
(2017) Journal of Internal Medicine, 282 p.508-521
Journal article

Interferon Regulatory Factor 5 Controls Necrotic Core Formation in Atherosclerotic Lesions by Impairing Efferocytosis

Anusha N. Seneviratne, Andreas Edsfeldt, Jennifer E. Cole, Christina Kassiteridi, Maarten Swart, et al.
(2017) Circulation, 136 p.1140-1154
Journal article

Circulating GDF-15 levels predict future secondary manifestations of cardiovascular disease explicitly in women but not men with atherosclerosis

Aisha Gohar, Isabel Gonçalves, Joyce Vrijenhoek, Saskia Haitjema, Ian van Koeverden, et al.
(2017) International Journal of Cardiology, 241 p.430-436
Journal article

Association between renin and atherosclerotic burden in subjects with and without type 2 diabetes

Isabel Gonçalves, Andreas Edsfeldt, Helen M. Colhoun, Angela C. Shore, Carlo Palombo, et al.
(2016) BMC Cardiovascular Disorders, 16 p.1-10
Journal article

Endarterectomy patients with elevated levels of circulating IL-16 have fewer cardiovascular events during follow-up

Caitríona Grönberg, Giuseppe Asciutto, Ana Persson, Gunilla Nordin Fredrikson, Jan Nilsson, et al.
(2016) Cytokine, 85 p.137-139
Journal article

Elevated CA125 is associated with incident heart failure and increased mortality in patients with acute coronary syndrome

T. Yndigegn, Anna Helena Maria Grufman, D. Erlinge, J Nilsson, I. Goncalves, et al.
(2016) European Heart Journal, 37 p.1392-1393
Conference paper: abstract

Apolipoprotein B-100 Antibody Interaction With Atherosclerotic Plaque Inflammation and Repair Processes.

Giuseppe Asciutto, Maria Wigren, Gunilla Nordin Fredrikson, Ingrid Yao Mattisson, Caitriona Grönberg, et al.
(2016) Stroke; a journal of cerebral circulation
Journal article

Decreased levels of stem cell factor in subjects with incident coronary events.

Maria Wigren, Sara Rattik, Karin Hultman, Harry Björkbacka, Gunilla Nordin Fredrikson, et al.
(2016) Journal of Internal Medicine, 279 p.180-191
Journal article

Glucose-Dependent Insulinotropic Polypeptide (GIP) Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.

Lisa Berglund, Valeriya Lyssenko, Claes Ladenvall, Olga Kotova, Andreas Edsfeldt, et al.
(2016) Diabetes, 65 p.239-254
Journal article

High levels of cathepsin D and cystatin B are associated with increased risk of coronary events.

Isabel Goncalves, Karin Hultman, Pontus Dunér, Andreas Edsfeldt, Bo Hedblad, et al.
(2016) Open Heart, 3 p.000353-000353
Journal article

High Plasma Levels of Galectin-3 Are Associated with Increased Risk for Stroke after Carotid Endarterectomy.

Andreas Edsfeldt, Eva Bengtsson, Giuseppe Asciutto, Pontus Dunér, Harry Björkbacka, et al.
(2016) Cerebrovascular Diseases, 41 p.199-203
Journal article

Determining carotid plaque vulnerability using ultrasound center frequency shifts.

Tobias Erlöv, Magnus Cinthio, Andreas Edsfeldt, Simon Segstedt, Nuno Dias, et al.
(2016) Atherosclerosis, 246 p.293-300
Journal article

Proinflammatory Role of Sphingolipids and Glycosphingolipids in the Human Atherosclerotic Plaque

Andreas Edsfeldt, Pontus Dunér, Marcus Ståhlman, Ines G Mollet, Giuseppe Asciutto, et al.
(2016) Arteriosclerosis, Thrombosis and Vascular Biology, 36 p.1132-1140
Journal article

Associations between macrophage colony-stimulating factor and monocyte chemotactic protein 1 in plasma and first-time coronary events : A Nested case-control Study

Alexandru Schiopu, Eva Bengtsson, Isabel Goncalves, Jan Nilsson, Gunilla Nordin Fredrikson, et al.
(2016) Journal of the American Heart Association, 5
Journal article

Galectin 3 is a powerful risk predictor for recurrent coronary events in acute coronary syndrome patients

A. Schiopu, T. Yndigegn, Anna Helena Maria Grufman, J. Nilsson, I. Goncalves
(2015) European Heart Journal, 36 p.11-11
Conference paper: abstract

Chronic Inflammation and Atherosclerosis

Jan Nilsson, Isabel Gonçalves, Andreas Edsfeldt
(2015) Early Vascular Aging (EVA) : New Directions in Cardiovascular Protection , p.157-167
Book chapter

Dystrophin deficiency reduces atherosclerotic plaque development in ApoE-null mice.

Annelie Shami, Anki Knutsson, Pontus Dunér, Uwe Rauch, Eva Bengtsson, et al.
(2015) Scientific Reports, 5
Journal article

Direct association between diet and the stability of human atherosclerotic plaque.

Isabel Goncalves, Elisavet Georgiadou, Sören Mattsson, Göran Skog, Luís Pedro, et al.
(2015) Scientific Reports, 5
Journal article

Low elastin content of carotid plaques is associated with increased risk of ipsilateral stroke.

Giuseppe Asciutto, Nuno Dias, Andreas Edsfeldt, Mihaela Nitulescu, Ana Persson, et al.
(2015) PLoS ONE, 10
Journal article

Coronary liposuction during percutaneous coronary intervention: evidence by near-infrared spectroscopy that aspiration reduces culprit lesion lipid content prior to stent placement.

David Erlinge, Jan Harnek, Isabel Goncalves, Matthias Götberg, James E Muller, et al.
(2015) European Heart Journal-Cardiovascular Imaging, 16 p.316-324
Journal article

High Plasma Levels of Heparin-Binding Epidermal Growth Factor Are Associated With a More Stable Plaque Phenotype and Reduced Incidence of Coronary Events.

Sara Rattik, Maria Wigren, Harry Björkbacka, Gunilla Nordin Fredrikson, Bo Hedblad, et al.
(2015) Arteriosclerosis, Thrombosis and Vascular Biology, 35 p.222-228
Journal article

Increased aldehyde-modification of collagen type IV in symptomatic plaques - A possible cause of endothelial dysfunction.

Pontus Dunér, Isabel Goncalves, Helena Grufman, Andreas Edsfeldt, Fong To, et al.
(2015) Atherosclerosis, 240 p.26-32
Journal article

Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.

Isabel Goncalves, Eva Bengtsson, Helen M Colhoun, Angela C Shore, Carlo Palombo, et al.
(2015) Arteriosclerosis, Thrombosis and Vascular Biology, 35 p.1723-1731
Journal article

Detecting the vulnerable plaque in patients.

Isabel Goncalves, H den Ruijter, M Nahrendorf, G Pasterkamp
(2015) Journal of Internal Medicine, 278 p.520-530
Journal article review

Human Carotid Plaques With High Levels of Interleukin-16 Are Associated With Reduced Risk for Cardiovascular Events.

Caitriona Grönberg, Eva Bengtsson, Gunilla Nordin Fredrikson, Mihaela Nitulescu, Giuseppe Asciutto, et al.
(2015) Stroke: a journal of cerebral circulation, 46 p.2748-2754
Journal article

Low levels of IgG autoantibodies against the apolipoprotein B antigen p210 increases the risk of cardiovascular death after carotid endarterectomy.

Giuseppe Asciutto, Nuno Dias, Andreas Edsfeldt, Ragnar Alm, Gunilla Nordin Fredrikson, et al.
(2015) Atherosclerosis, 239 p.289-294
Journal article

Circulating cytokines reflect the expression of pro-inflammatory cytokines in atherosclerotic plaques.

Andreas Edsfeldt, Helena Grufman, Giuseppe Asciutto, Mihaela Nitulescu, Ana Persson, et al.
(2015) Atherosclerosis, 241 p.443-449
Journal article

Expression of fibromodulin in carotid atherosclerotic plaques is associated with diabetes and cerebrovascular events.

Annelie Shami, Christoffer Tengryd, Giuseppe Asciutto, Eva Bengtsson, Jan Nilsson, et al.
(2015) Atherosclerosis, 241 p.701-708
Journal article

DNA Methylation Dynamics in Human Carotid Plaques After Cerebrovascular Events.

Silvio Zaina, Isabel Goncalves, F Javier Carmona, Antonio Gomez, Holger Heyn, et al.
(2015) Arteriosclerosis, Thrombosis and Vascular Biology, 35 p.1835-1842
Journal article

ATG16L1 Expression in Carotid Atherosclerotic Plaques Is Associated With Plaque Vulnerability.

Joelle Magné, Peter Gustafsson, Hong Jin, Lars Maegdefessel, Kjell Hultenby, et al.
(2015) Arteriosclerosis, Thrombosis and Vascular Biology, 35 p.1226-1235
Journal article

Measures of atherosclerotic burden are associated with clinically manifest cardiovascular disease in type 2 diabetes: a European cross-sectional study

A. C. Shore, H. M. Colhoun, A. Natali, C. Palombo, Gerd Östling, et al.
(2015) Journal of Internal Medicine, 278 p.291-302
Journal article

Atherosclerosis and general principles of arterial imaging.

Isabel Goncalves, Nuno Dias, Peter M Nilsson
(2015) Assessment of Preclinical Organ Damage in Hypertension , p.81-95
Book chapter

Imaging and Ageing of the Aorta and Large Arteries in the Lower Extremity

Nuno Dias, Isabel Goncalves, Peter Nilsson
(2015) Assessment of Preclinical Organ Damage in Hypertension , p.97-114
Book chapter

Treatment with betablockers is associated with higher grey-scale median in carotid plaques

Giuseppe Asciutto, Nuno Dias, Ana Persson, Jan Nilsson, Isabel Goncalves
(2014) BMC Cardiovascular Disorders, 14
Journal article

Collagen and related extracellular matrix proteins in atherosclerotic plaque development.

Annelie Shami, Isabel Goncalves, Anna Hultgårdh
(2014) Current Opinion in Lipidology, 25 p.394-399
Journal article review

Evidence for altered inflammatory and repair responses in symptomatic carotid plaques from elderly patients.

Helena Grufman, Alexandru Schiopu, Andreas Edsfeldt, Harry Björkbacka, Mihaela Nitulescu, et al.
(2014) Atherosclerosis, 237 p.177-182
Journal article

A DNA Methylation Map of Human Atherosclerosis.

Silvio Zaina, Holger Heyn, F Javier Carmona, Nuray Varol, Sergi Sayols, et al.
(2014) Circulation: Cardiovascular Genetics, 7 p.692-700
Journal article

Impaired Fibrous Repair: A Possible Contributor to Atherosclerotic Plaque Vulnerability in Patients With Type II Diabetes.

Andreas Edsfeldt, Isabel Goncalves, Helena Grufman, Mihaela Nitulescu, Pontus Dunér, et al.
(2014) Arteriosclerosis, Thrombosis and Vascular Biology, 34 p.2143-2150
Journal article

Long-term progression of contralateralcarotid artery disease after endarterectomy: is there a need for Duplex surveillance?

Giuseppe Asciutto, Jonatan Wistrand, L Riva, Katarina Björses, Isabel Goncalves, et al.
(2014) International Angiology, 33 p.300-300
Journal article (letter)

Plasma levels of high-sensitive C-reactive protein do not correlate with inflammatory activity in carotid atherosclerotic plaques.

Helena Grufman, Isabel Goncalves, Andreas Edsfeldt, Mihaela Nitulescu, Ana Persson, et al.
(2014) Journal of Internal Medicine, 275 p.127-133
Journal article

Histologic and biochemical composition of carotid plaque and its impact on ultrasonographic appearance.

Isabel Goncalves
(2014) Multi-modality atherosclerosis imaging, diagnosis and treatment , p.199-207
Book chapter

Treatment with beta-blockers is associated with lower levels of Lp-PLA2 and suPAR in carotid plaques.

Giuseppe Asciutto, Andreas Edsfeldt, Nuno Dias, Jan Nilsson, Cornelia Prehn, et al.
(2013) Cardiovascular Pathology, 22 p.438-443
Journal article

Comparison of grey scale median (GSM) measurement in ultrasound images of human carotid plaques using two different softwares.

Gerd Östling, Margaretha Persson, Bo Hedblad, Isabel Goncalves
(2013) Clinical Physiology and Functional Imaging, 33 p.431-435
Journal article

Attenuation of Experimental Atherosclerosis by Interleukin-19.

Stephen Ellison, Khatuna Gabunia, Sheri E Kelemen, Ross N England, Rosario Scalia, et al.
(2013) Arteriosclerosis, Thrombosis and Vascular Biology, 33 p.2316-2324
Journal article

Potential Influence of Diet on Bomb-Pulse Dating of Human Plaque Samples

Elisavet Georgiadou, Isabel Goncalves, Cintia Bertacchi Uvo, Jan Nilsson, Göran Skog, et al.
(2013) Radiocarbon, 55 p.874-884
Journal article

NFAT regulates the expression of AIF-1 and IRT-1: Yin and yang splice variants of neointima formation and atherosclerosis.

Lisa Berglund, Olga Kotova, Peter Osmark, Helena Grufman, Chen Xing, et al.
(2012) Cardiovascular Research, 93 p.414-423
Journal article

Soluble Urokinase Plasminogen Activator Receptor is Associated With Inflammation in the Vulnerable Human Atherosclerotic Plaque.

Andreas Edsfeldt, Mihaela Nitulescu, Helena Grufman, Caitriona Grönberg, Ana Persson, et al.
(2012) Stroke; a journal of cerebral circulation, 43 p.3305-3312
Journal article

Evidence Supporting a Key Role of Lp-PLA2-Generated Lysophosphatidylcholine in Human Atherosclerotic Plaque Inflammation.

Isabel Goncalves, Andreas Edsfeldt, Na Young Ko, Helena Grufman, Katarina Berg, et al.
(2012) Arteriosclerosis, Thrombosis and Vascular Biology, 32 p.1505-1505
Journal article

Long-term progression of contralateral carotid artery disease after endarterectomy: is there a need for Duplex surveillance?

Giuseppe Asciutto, Jonatan Wistrand, L Riva, Katarina Björses, Isabel Goncalves, et al.
(2012) International Angiology, 31 p.361-367
Journal article

Activity Index: a tool to identify active carotid plaques.

Luís Pedro, Isabel Goncalves, R Fernandes e Fernandes, J Seabra, JM Sanches, et al.
(2012) Ultrasound Imaging: Advances and Applications , p.163-175
Book chapter

Long-term treatment with low-dose metoprolol CR/XL is associated with increased plaque echogenicity: The Beta-blocker Cholesterol-lowering Asymptomatic Plaque Study (BCAPS).

Gerd Östling, Isabel Goncalves, John Wikstrand, Göran Berglund, Jan Nilsson, et al.
(2011) Atherosclerosis, 215 p.440-445
Journal article

Activator protein-1 in carotid plaques is related to cerebrovascular symptoms and cholesteryl ester content.

Isabel Goncalves, Maria Stollenwerk, Marie Lindholm, Nuno Dias, Luís M Pedro, et al.
(2011) Cardiovascular Pathology, 20 p.36-43
Journal article

Low carotid calcium score is associated with higher levels of glycosaminoglycans, tumor necrosis factor-alpha, and parathyroid hormone in human carotid plaques.

Andreas Edsfeldt, Nuno Dias, Barbara Elmståhl, Markus Müller, Katarina Berg, et al.
(2011) Stroke; a journal of cerebral circulation, 42 p.458-2966
Journal article

Patofysiologi och epidemiologi

Isabel Goncalves, Nuno Dias
(2011) Vård och behandling vid kärlsjukdomar , p.73-80
Book chapter

Dating Components of Human Atherosclerotic Plaques

Isabel Goncalves, Kristina Stenström, Göran Skog, Sören Mattsson, Mihaela Nitulescu, et al.
(2010) Circulation Research, 106 p.1174-1177
Journal article

Changing From Conventional to Eversion Endarterectomy in Carotid Artery Disease-A Safe Transition Process in the Short and Long Term

Jonatan Wistrand, Thomas Mätzsch, Isabel Goncalves, Lorenzo Riva, Nuno Dias
(2010) Vascular and Endovascular Surgery, 44 p.539-544
Journal article

Coagulation activation and ultrasound characteristics in patients with carotid artery disease.

Tilo Kölbel, Isabel Goncalves, Nuno Dias, Karin Strandberg, Stefan Acosta, et al.
(2010) Thrombosis Research, 125 p.171-177
Journal article

Hemodynamics and jugular venous oxygen saturation during carotid endarterectomy: a comparison between general and locoregional anesthesia.

Nuno Dias, Tilo Kölbel, Isabel Goncalves, Michelle Chew, Jonatan Wistrand, et al.
(2010) International Angiology, 29 p.232-238
Journal article

Activation of calpain-1 in human carotid artery atherosclerotic lesions

Isabel Goncalves, Mihaela Nitulescu, Takaomi C. Saido, Nuno Dias, Luis M. Pedro, et al.
(2009) BMC Cardiovascular Disorders, 9
Journal article

Immune responses against fibronectin modified by lipoprotein oxidation and their association with cardiovascular disease.

Pontus Dunér, Fong To, Ragnar Alm, Isabel Goncalves, Gunilla Nordin Fredrikson, et al.
(2009) Journal of Internal Medicine, Feb 14. p.593-603
Journal article

Identification of the target for therapeutic recombinant anti-apoB-100 peptide antibodies in human atherosclerotic lesions.

Isabel Goncalves, Mihaela Nitulescu, Mikko Ares, Gunilla Nordin Fredrikson, Bo Jansson, et al.
(2009) Atherosclerosis, 205 p.96-100
Journal article

Effects of simvastatin on circulating autoantibodies to oxidized LDL antigens: relation with immune stimulation markers.

Isabel Goncalves, Pierre Cherfan, Ingrid Söderberg, Gunilla Nordin Fredrikson, Lena Jonasson
(2009) Autoimmunity, 42 p.203-208
Journal article

Elastin- and Collagen-Rich Human Carotid Plaques Have Increased Levels of the Cysteine Protease Inhibitor Cystatin C.

Isabel Goncalves, Mikko P S Ares, Anna Moberg, Jonatan Moses, Fong To, et al.
(2008) Journal of Vascular Research, 45 p.395-401
Journal article

Increased Echolucency of Carotid Plaques in Patients With Type 2 Diabetes.

Gerd Östling, Bo Hedblad, Göran Berglund, Isabel Goncalves
(2007) Stroke: a journal of cerebral circulation, 38 p.2074-2078
Journal article

Immunomodulation of atherosclerosis

Jan Nilsson, Gunilla Nordin Fredrikson, Alexandru Schiopu, Isabel Goncalves, KY Chyu, et al.
(2007) The Vulnerable Plaque , p.371-382
Book chapter

Pode a ultrasonografia carotídea reflectir a composição da placa aterosclerótica vulnerável?

Isabel Goncalves, Luís M Pedro, Nuno Dias, Marie Lindholm, Gunilla Fredrikson, et al.
(2007) Angiologia e Cirurgia Vascular, 3 p.93-96
Journal article

C4b-binding protein binds to necrotic cells and DNA, limiting DNA release and inhibiting complement activation.

Leendert Trouw, Sara Nilsson, Isabel Goncalves, Göran Landberg, Anna Blom
(2005) Journal of Experimental Medicine, 201 p.1937-1948
Journal article

Humoral Immune Response Against Defined Oxidized Low-Density Lipoprotein Antigens Reflects Structure and Disease Activity of Carotid Plaques.

Isabel Goncalves, Marie-Louise M Gronholdt, Ingrid Söderberg, Mikko Ares, Borge G Nordestgaard, et al.
(2005) Arteriosclerosis, Thrombosis and Vascular Biology, 25 p.1250-1255
Journal article

Kan man hitta instabila karotisplack med ultraljud?

Isabel Goncalves, Jan Nilsson, Mikko Ares
(2005) Kärilet, 17 p.4-6
Journal article

Elastin and calcium rather than collagen or lipid content are associated with echogenicity of human carotid plaques.

Isabel Goncalves, Marie Lindholm, Luis M Pedro, Nuno Dias, José Fernandes e Fernandes, et al.
(2004) Stroke: a journal of cerebral circulation, 35 p.2795-2800
Journal article

Assessing carotid plaque structure

Isabel Goncalves
(2004)
Dissertation

Changes related to age and cerebrovascular symptoms in the extracellular matrix of human carotid plaques.

Isabel Goncalves, Jonatan Moses, Nuno Dias, Luís M Pedro, José Fernandes e Fernandes, et al.
(2003) Stroke: a journal of cerebral circulation, 34 p.616-622
Journal article

Echolucency of carotid plaques correlates with plaque cellularity.

Isabel Goncalves, J. Moses, L. Pedro, N. Dias, J. Fernandes, et al.
(2003) European Journal of Vascular and Endovascular Surgery, 26 p.32-38
Journal article

Ultrasonographic risk score of carotid plaques

L M Pedro, J Fernandes e Fernandes, M M Pedro, I Goncalves, Nuno Dias, et al.
(2002) European Journal of Vascular and Endovascular Surgery, 24 p.492-498
Journal article

Beta-estradiol effect on erythrocyte aggregation--a controlled in vitro study

Isabel Goncalves, C Saldanha, J Martins e Silva
(2001) Clinical Hemorheology and Microcirculation, 25 p.127-134
Journal article

Carotoid plaque characterisation. A new ultrasonographic activity index.

L M Pedro, M M Pedro, Isabel Goncalves, Nuno Dias, R Fernandes e Fernandes, et al.
(2001) Cerebrovascular Diseases, 11 p.5-5
Conference paper: abstract

Carotid plaque characterisation. A new ultrasonographic activity index

Luís Pedro, M M Pedro, Isabel Goncalves, Nuno Dias, R Fernandes e Fernandes, et al.
(2001) Cerebrovascular Diseases, 11 p.5-5
Conference paper: abstract

Computer-assisted carotid plaque analysis: characteristics of plaques associated with cerebrovascular symptoms and cerebral infarction

L M Pedro, M M Pedro, Isabel Goncalves, T F Carneiro, C Balsinha, et al.
(2000) European Journal of Vascular and Endovascular Surgery, 19 p.118-123
Journal article

Very low-density lipoprotein activates nuclear factor-kappaB in endothelial cells

W Dichtl, L Nilsson, Isabel Goncalves, Mikko Ares, C Banfi, et al.
(1999) Circulation Research, 84 p.1085-1094
Journal article

Oxidized LDL and lysophosphatidylcholine stimulate plasminogen activator inhibitor-1 expression in vascular smooth muscle cells

Wolfgang Dichtl, Ann Stiko, Per Eriksson, Isabel Goncalves, Frederico Calara, et al.
(1999) Arteriosclerosis, Thrombosis, and Vascular Biology, 19 p.32-3025
Journal article

Placa de ateroma da bifurcacao carotidea: como identificar a lesao "activa"?

L M Pedro, M M Pedro, Isabel Goncalves, T F Carneiro, C Balsinha, et al.
(1999) Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology, 18 p.699-708
Journal article

Oubain role on erythrocyte/fibrinogen interaction

Isabel Goncalves, Rui Mesquita, C Saldanha, J Martins e Silva
(1999) Blood Coagulation and Fibrinolysis, 10 p.107-107
Conference paper: abstract

Ethanol and erythrocyte membrane interaction: a hemorheologic perspective.

Rui Mesquita, Isabel Goncalves, S Dias, Luís Sargento, C Saldanha, et al.
(1999) Clinical Hemorheology and Microcirculation, 21 p.95-98
Journal article

Estudo in vivo da parede arterial no aterosclerose: impacto dosfactores de risco e correlação com a cardiopatia isquernica

M M Pedro, L M Pedro, R Fernandes e Fernandes, T F Carneiro, C Balsinha, et al.
(1998) , p.31-31
Conference paper: abstract

Fibrinogénio e agregação eritrocitária

Rui Mesquita, Isabel Goncalves, C Saldanha, J Martins e Silva
(1998) Boletim da SPHM (Sociedade Portuguesa de Hemorreologia e Microcirculação), 13 p.28-28
Journal article (comment)

The Evaluation Of The Arterial Wall By High Definition Ultrassonography: The Impact Of The Atherosclerotic Risk Factors And its Relation With Advanced Forms of the Disease

M M Pedro, L M Pedro, R Fernandes e Fernandes, T F Carneiro, C Balsinha, et al.
(1997) , p.62-62
Conference paper: abstract

Uma janela para a aterosclerose: A Ecografia de alta definição no estudo da parede arterial

Luís Pedro, M M Pedro, R Fernandes e Fernandes, T F Carneiro, C Balsinha, et al.
(1997) Jornal das Ciências Médicas, 161 p.37-61
Journal article

Efeito in vitro do etanolna membrana eritrocitária

Luís Sargento, Isabel Goncalves, Rui Mesquita, Sonia Pimentel, C Saldanha, et al.
(1995) Boletim da SPHM (Sociedade Portuguesa de Hemorreologia e Microcirculação), 10 p.22-22
Journal article (comment)