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Isabel Drake

Isabel Drake

Associate professor

Isabel Drake

Consumption of fruits, vegetables and fruit juices and differentiated thyroid carcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study


  • Raul Zamora-Ros
  • Virginie Béraud
  • Silvia Franceschi
  • Valerie Cayssials
  • Konstantinos K. Tsilidis
  • Marie Christine Boutron-Ruault
  • Elisabete Weiderpass
  • Kim Overvad
  • Anne Tjønneland
  • Anne K. Eriksen
  • Fabrice Bonnet
  • Aurélie Affret
  • Verena Katzke
  • Tilman Kühn
  • Heiner Boeing
  • Antonia Trichopoulou
  • Elisavet Valanou
  • Anna Karakatsani
  • Giovanna Masala
  • Sara Grioni
  • Maria Santucci de Magistris
  • Rosario Tumino
  • Fulvio Ricceri
  • Guri Skeie
  • Christine L. Parr
  • Susana Merino
  • Elena Salamanca-Fernández
  • Maria Dolores Chirlaque
  • Eva Ardanaz
  • Pilar Amiano
  • Martin Almquist
  • Isabel Drake
  • Joakim Hennings
  • Maria Sandström
  • H. Bas Bueno-de-Mesquita
  • Petra H. Peeters
  • Kay Thee Khaw
  • Nicholas J. Wareham
  • Julie A. Schmidt
  • Aurora Perez-Cornago
  • Dagfinn Aune
  • Elio Riboli
  • Nadia Slimani
  • Augustin Scalbert
  • Isabelle Romieu
  • Antonio Agudo
  • Sabina Rinaldi

Summary, in English

Fruit and vegetable (F&V) intake is considered as probably protective against overall cancer risk, but results in previous studies are not consistent for thyroid cancer (TC). The purpose of this study is to examine the association between the consumption of fruits, vegetables, fruit juices and differentiated thyroid cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The EPIC study is a cohort including over half a million participants, recruited between 1991 and 2000. During a mean follow-up of 14 years, 748 incident first primary differentiated TC cases were identified. F&V and fruit juice intakes were assessed through validated country-specific dietary questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression models adjusted for potential confounding factors. Comparing the highest versus lowest quartile of intake, differentiated TC risk was not associated with intakes of total F&V (HR: 0.89; 95% CI: 0.68–1.15; p-trend = 0.44), vegetables (HR: 0.89; 95% CI: 0.69–1.14; p-trend = 0.56), or fruit (HR: 1.00; 95% CI: 0.79–1.26; p-trend = 0.64). No significant association was observed with any individual type of vegetable or fruit. However, there was a positive borderline trend with fruit juice intake (HR: 1.23; 95% CI: 0.98–1.53; p-trend = 0.06). This study did not find any significant association between F&V intakes and differentiated TC risk; however a positive trend with fruit juice intake was observed, possibly related to its high sugar content.


  • Surgery (Lund)
  • Endocrine and Sarcoma Surgery
  • Diabetes - Cardiovascular Disease
  • EpiHealth: Epidemiology for Health

Publishing year







International Journal of Cancer





Document type

Journal article


John Wiley & Sons Inc.


  • Cancer and Oncology


  • EPIC
  • fruit juices
  • fruits
  • intake
  • thyroid cancer
  • vegetables



Research group

  • Endocrine and Sarcoma Surgery
  • Diabetes - Cardiovascular Disease


  • ISSN: 0020-7136