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Hindrik Mulder

Hindrik Mulder

Principal investigator

Hindrik Mulder

The pathogenetic role of β-cell mitochondria in type 2 diabetes

Author

  • Malin Fex
  • Lisa M. Nicholas
  • Neelanjan Vishnu
  • Anya Medina
  • Vladimir V. Sharoyko
  • David G. Nicholls
  • Peter Spégel
  • Hindrik Mulder

Summary, in English

Mitochondrial metabolism is a major determinant of insulin secretion from pancreatic β-cells. Type 2 diabetes evolves when β-cells fail to release appropriate amounts of insulin in response to glucose. This results in hyperglycemia and metabolic dysregulation. Evidence has recently been mounting that mitochondrial dysfunction plays an important role in these processes. Monogenic dysfunction of mitochondria is a rare condition but causes a type 2 diabetes-like syndrome owing to β-cell failure. Here, we describe novel advances in research on mitochondrial dysfunction in the β-cell in type 2 diabetes, with a focus on human studies. Relevant studies in animal and cell models of the disease are described. Transcriptional and translational regulation in mitochondria are particularly emphasized. The role of metabolic enzymes and pathways and their impact on β-cell function in type 2 diabetes pathophysiology are discussed. The role of genetic variation in mitochondrial function leading to type 2 diabetes is highlighted. We argue that alterations in mitochondria may be a culprit in the pathogenetic processes culminating in type 2 diabetes.

Department/s

  • Diabetes - Molecular Metabolism
  • Diabetes and Celiac Unit
  • Genetic and Molecular Epidemiology
  • Department of Experimental Medical Science
  • Genomics, Diabetes and Endocrinology
  • Centre for Analysis and Synthesis
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2018

Language

English

Pages

145-149

Publication/Series

Journal of Endocrinology

Volume

236

Issue

3

Document type

Journal article review

Publisher

Society for Endocrinology

Topic

  • Endocrinology and Diabetes

Keywords

  • Coupling signal
  • Genetic variation
  • Mitochondrial transcription
  • Oxidative phosphorylation
  • TCA cycle

Status

Published

Research group

  • Diabetes - Molecular Metabolism
  • Diabetes and Celiac Unit
  • Genetic and Molecular Epidemiology
  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 0022-0795