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Hindrik Mulder

Hindrik Mulder

Principal investigator

Hindrik Mulder

Matrix Metalloproteinases - keys to healthier blood vessels in diabetes?

Author

  • Hindrik Mulder

Summary, in English

In this issue of J Endocrinol, Schuyler et al. show that intimal lesions in atherosclerosis-prone diabetic apoE-/- mice are reduced by insulin treatment. An increase of metalloproteinase-9 expression was observed in untreated diabetic apoE-/- mice; this was absent in insulin-treated mice. The study suggests that hindering of tissue-remodeling metalloproteinases may account for the beneficial effects of proper metabolic control in patients with diabetes. This clinically relevant finding prompts further exploration.

Department/s

  • Diabetes - Molecular Metabolism
  • EXODIAB: Excellence in Diabetes Research in Sweden

Publishing year

2011

Language

English

Pages

1-2

Publication/Series

Journal of Endocrinology

Volume

210

Issue

1

Document type

Journal article

Publisher

Society for Endocrinology

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Diabetes - Molecular Metabolism

ISBN/ISSN/Other

  • ISSN: 1479-6805