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Hindrik Mulder

Hindrik Mulder

Principal investigator

Hindrik Mulder

Pituitary adenylate cyclase-activating peptide is upregulated in sensory neurons by inflammation

Author

  • Y Zhang
  • N Danielsen
  • F Sundler
  • H Mulder

Summary, in English

The neuropeptide pituitary adenylate cyclase-activating peptide (PACAP) is expressed in sensory neurons. Expression of several neuropeptides is up-regulated in sensory neurons following inflammation. To examine whether also PACAP expression is regulated by inflammation, PACAP expression in L5 dorsal root ganglion (DRG) was determined, using in situ hybridization, after unilateral adjuvant-induced inflammation in the rat paw. At 12 h and day 3, but not day 21, the percentage of neurons expressing PACAP mRNA was greater in the innervating L5 DRG. Similarly, PACAP mRNA expression in individual neurons was higher in the innervating L5 DRG at 12 h and day 3, but not day 21. Up-regulated PACAP expression following adjuvant injection suggests a role for PACAP in inflammation.

Department/s

  • Neuronano Research Center (NRC)
  • Neural Interfaces
  • Neuroendocrine Cell Biology
  • Diabetes - Molecular Metabolism

Publishing year

1998-08-24

Language

English

Pages

2833-2836

Publication/Series

NeuroReport

Volume

9

Issue

12

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Basic Medicine

Keywords

  • Animals
  • Female
  • Freund's Adjuvant
  • Ganglia, Spinal
  • In Situ Hybridization
  • Inflammation
  • Neurons, Afferent
  • Neuropeptides
  • Pituitary Adenylate Cyclase-Activating Polypeptide
  • RNA, Messenger
  • Rats
  • Rats, Sprague-Dawley
  • Up-Regulation
  • Journal Article
  • Research Support, Non-U.S. Gov't

Status

Published

Research group

  • Neuronano Research Center (NRC)
  • Neural Interfaces
  • Neuroendocrine Cell Biology
  • Diabetes - Molecular Metabolism

ISBN/ISSN/Other

  • ISSN: 0959-4965