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Hindrik Mulder

Hindrik Mulder

Principal investigator

Hindrik Mulder

The Human Diabetes Proteome Project (HDPP) : The 2014 update

Author

  • D. Schvartz
  • Patrik Bergsten
  • K. H. Baek
  • A. Barba De La Rosa
  • J. Cantley
  • L. Dayon
  • F. Finamore
  • P. Fontana
  • P. Gaudet
  • Y. A. Goo
  • R. Moulder
  • David R Goodlett
  • J. D. Johnson
  • A. Konvalinka
  • Hindrik Mulder
  • F. Priego-Capote
  • Salvatore Sechi
  • Kathleen M. Snyder
  • A. Tiss
  • A. Wiederkehr
  • I. Xenarios
  • Martin Kussmann
  • J. C. Sanchez

Summary, in English

Diabetes is an increasing worldwide problem leading to major associated health issues and increased health care costs. In 2012, 9.3% of the American population was affected by diabetes, according to the American Diabetes Association, with 1.7 million of new cases since during the year (www.diabetes.org). Proteome initiatives can provide a deeper understanding of the biology of this disease and help develop more effective treatments. The collaborative effort of the Human Diabetes Proteome Project (HDPP) brings together a wide variety of complementary resources to increase the existing knowledge about both type 1 and type 2 diabetes and their related complications. The goals are to identify proteins and protein isoforms associated with the pathology and to characterize underlying disease-related pathways and mechanisms. Moreover, a considerable effort is being made on data integration and network biology. Sharing these data with the scientific community will be an important part of the consortium. Here we report on: the content of the HDPP session held at the 12th HUPO meeting in Yokohama; recent achievements of the consortium; discussions of several HDPP workshops; as well as future HDPP directions as discussed at the 13th HUPO congress in Madrid, with a special attention given to the lists of prioritized, diabetes-related proteins and the proteomic means to study them.

Department/s

  • Diabetes - Molecular Metabolism
  • EXODIAB: Excellence in Diabetes Research in Sweden

Publishing year

2015-12-01

Language

English

Pages

1-7

Publication/Series

Translational Proteomics

Volume

8-9

Document type

Journal article

Publisher

Elsevier

Topic

  • Endocrinology and Diabetes
  • Cell and Molecular Biology

Keywords

  • B/D-HPP
  • Blood
  • Diabetes
  • HDPP
  • HPP
  • Human proteome
  • Islet
  • Network biology

Status

Published

Research group

  • Diabetes - Molecular Metabolism

ISBN/ISSN/Other

  • ISSN: 2212-9626