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Hindrik Mulder

Hindrik Mulder

Principal investigator

Hindrik Mulder

Localization of hormone-sensitive lipase to rat Sertoli cells and its expression in developing and degenerating testes

Author

  • Lena Stenson
  • Anna Maria Hoffmann
  • Hindrik Mulder
  • Frank Sundler
  • Cecilia Holm
  • Anders Bergh
  • Gudrun Fredrikson

Summary, in English

Using in situ hybridization, hormone-sensitive lipase was found to be expressed in a stage-dependent manner in Sertoli cells of rat testis. No expression was found in Leydig cells but expression in spermatids could not be excluded. These results suggest a role for hormone-sensitive lipase in the metabolism of lipid droplets in Sertoli cells, in contrast to its previously proposed function in steroid biosynthesis. The expression of testicular hormone-sensitive lipase mRNA and protein, both larger in size compared to other tissues, coincided with the onset of spermatogenesis and was dependent on scrotal localization of the testis, suggesting a temperature-dependent, pretranslational regulation of expression.

Department/s

  • Insulin Signal Transduction
  • Department of Experimental Medical Science
  • Molecular Endocrinology

Publishing year

1994

Language

English

Pages

125-130

Publication/Series

FEBS Letters

Volume

355

Issue

2

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Biological Sciences

Keywords

  • Hormone sensitive lipase
  • Cholesterol ester hydrolase
  • Testis
  • Sertoli cell
  • In situ hybridization

Status

Published

Research group

  • Insulin Signal Transduction
  • Molecular Endocrinology

ISBN/ISSN/Other

  • ISSN: 1873-3468