The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here:

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Hindrik Mulder

Hindrik Mulder

Principal investigator

Hindrik Mulder

The GTPase domain of gamma-tubulin is required for normal mitochondrial function and spatial organization


  • Lisa Lindström
  • Tongbin Li
  • Darina Malycheva
  • Arun Kancharla
  • Helén Nilsson
  • Neelanjan Vishnu
  • Hindrik Mulder
  • Martin Johansson
  • Catalina Ana Rosselló
  • Maria Alvarado-Kristensson

Summary, in English

In the cell, γ-tubulin establishes a cellular network of threads named the γ-string meshwork. However, the functions of this meshwork remain to be determined. We investigated the traits of the meshwork and show that γ-strings have the ability to connect the cytoplasm and the mitochondrial DNA together. We also show that γ-tubulin has a role in the maintenance of the mitochondrial network and functions as reduced levels of γ-tubulin or impairment of its GTPase domain disrupts the mitochondrial network and alters both their respiratory capacity and the expression of mitochondrial-related genes. By contrast, reduced mitochondrial number or increased protein levels of γ-tubulin DNA-binding domain enhanced the association of γ-tubulin with mitochondria. Our results demonstrate that γ-tubulin is an important mitochondrial structural component that maintains the mitochondrial network, providing mitochondria with a cellular infrastructure. We propose that γ-tubulin provides a cytoskeletal element that gives form to the mitochondrial network.


  • Molecular Pathology, Malmö
  • Clinical pathology, Malmö
  • Diabetes - Molecular Metabolism
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation

Publishing year





Communications Biology




Document type

Journal article


Nature Research


  • Cell and Molecular Biology



Research group

  • Molecular Pathology, Malmö
  • Clinical pathology, Malmö
  • Diabetes - Molecular Metabolism


  • ISSN: 2399-3642