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Hindrik Mulder

Hindrik Mulder

Principal investigator

Hindrik Mulder

Distribution of melatonin receptors in murine pancreatic islets.

Author

  • Cecilia Nagorny
  • Ramasri Sathanoori
  • Ulrikke Voss
  • Hindrik Mulder
  • Nils Wierup

Summary, in English

Melatonin has multiple receptor-dependent and receptor-independent functions. At the cell membrane, melatonin interacts with its receptors MT1 and MT2, which are expressed in numerous tissues. Genome-wide association studies have recently shown that the MTNR1B/MT2 receptor may be involved in the pathogenesis of type 2 diabetes mellitus. In line with these findings, expression of melatonin receptors has been shown in mouse, rat, and human pancreatic islets. MT1 and MT2 are G-protein-coupled receptors and are proposed to exert inhibitory effects on insulin secretion. Here, we show by immunocytochemistry that these membrane melatonin receptors have distinct locations in the mouse islet. MT1 is expressed in α-cells while MT2 is located to the β-cells. These findings help to unravel the complex machinery underlying melatonin's role in the regulation of islet function.

Department/s

  • Department of Experimental Medical Science
  • Cardiology
  • Neurogastroenterology
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2011

Language

English

Pages

412-417

Publication/Series

Journal of Pineal Research

Volume

50

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Cardiac and Cardiovascular Systems
  • Gastroenterology and Hepatology
  • Endocrinology and Diabetes
  • Cell and Molecular Biology

Status

Published

Research group

  • Neurogastroenterology

ISBN/ISSN/Other

  • ISSN: 1600-079X