Hindrik Mulder

Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion

N. Vishnu, A. Hamilton, A. Bagge, A. Wernersson, E. Cowan, et al.
(2021) Molecular Metabolism, 51
Journal article

The MafA-target gene PPP1R1A regulates GLP1R-mediated amplification of glucose-stimulated insulin secretion in β-cells

Luis Rodrigo Cataldo, Neelanjan Vishnu, Tania Singh, Ludivine Bertonnier-Brouty, Sara Bsharat, et al.
(2021) Metabolism: Clinical and Experimental
Journal article

The times they are a-changin’

Hindrik Mulder
(2021) Diabetologia, 64 p.3-4
Journal article (comment)

Look beyond the impact factor

Hindrik Mulder
(2021) Diabetologia, 64 p.2129-2130
Journal article (comment)

Genomic editing of metformin efficacy-associated genetic variants in SLC47A1 does not alter SLC47A1 expression

Sebastian Kalamajski, Mi Huang, Jonathan Dalla-Riva, Maria Keller, Adem Y Dawed, et al.
(2021) Human Molecular Genetics
Journal article

Roger H. Unger, 7 March 1924-22 August 2020

Hindrik Mulder
(2020) Diabetologia, 63 p.2497-2498
Journal article (comment)

Metabolomics Analysis of Nutrient Metabolism in β-Cells

Peter Spégel, Hindrik Mulder
(2020) Journal of Molecular Biology, 432 p.1429-1445
Journal article review

Insulin/Glucose-Responsive Cells Derived from Induced Pluripotent Stem Cells: Disease Modeling and Treatment of Diabetes

Sevda Gheibi, Tania Singh, Joao Paulo M. C. M. da Cunha, Malin Fex, Hindrik Mulder
(2020) Cells, 9
Journal article review

Att inte debattera är inte ett alternativ

Karin Broberg, Ingrid Dunér, Kristofer Hansson, Mats Hansson, Johan Jakobsson, et al.
(2019) Svenska Dagbladet, Stockholm
Newspaper article

Vi måste ta ställning till den nya gentekniken

Karin Broberg, Ingrid Dunér, Kristofer Hansson, Mats Hansson, Johan Jakobsson, et al.
(2019) Svenska Dagbladet, Stockholm
Newspaper article

Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production

Jakob G Knudsen, Alexander Hamilton, Reshma Ramracheya, Andrei I Tarasov, Melissa Brereton, et al.
(2019) Cell Metabolism, 29 p.4-442
Journal article

The GTPase domain of gamma-tubulin is required for normal mitochondrial function and spatial organization

Lisa Lindström, Tongbin Li, Darina Malycheva, Arun Kancharla, Helén Nilsson, et al.
(2018) Communications Biology, 1
Journal article

Novel subgroups of adult-onset diabetes and their association with outcomes : A data-driven cluster analysis of six variables

Emma Ahlqvist, Petter Storm, Annemari Käräjämäki, Mats Martinell, Mozhgan Dorkhan, et al.
(2018) The Lancet Diabetes and Endocrinology, 6 p.361-369
Journal article

Glutamine-elicited secretion of glucagon-like peptide 1 is governed by an activated glutamate dehydrogenase

Lotta E. Andersson, Liliya Shcherbina, Mahmoud Al-Majdoub, Neelanjan Vishnu, Claudia Balderas Arroyo, et al.
(2018) Diabetes, 67 p.372-384
Journal article

The effects of high glucose exposure on global gene expression and DNA methylation in human pancreatic islets

Elin Hall, Marloes Dekker Nitert, Petr Volkov, Siri Malmgren, Hindrik Mulder, et al.
(2018) Molecular and Cellular Endocrinology, 472 p.57-67
Journal article

The pathogenetic role of β-cell mitochondria in type 2 diabetes

Malin Fex, Lisa M. Nicholas, Neelanjan Vishnu, Anya Medina, Vladimir V. Sharoyko, et al.
(2018) Journal of Endocrinology, 236 p.145-149
Journal article review

Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes

Julie Adam, Reshma Ramracheya, Margarita V. Chibalina, Nicola Ternette, Alexander Hamilton, et al.
(2017) Cell Reports, 20 p.3135-3148
Journal article

Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic β-cells

Lisa M. Nicholas, Bérengère Valtat, Anya Medina Benavente, Lotta Andersson, Mia Abels, et al.
(2017) Molecular Metabolism, 6 p.651-663
Journal article

Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes

Annika S. Axelsson, Emily Tubbs, Brig Mecham, Shaji Chacko, Hannah A. Nenonen, et al.
(2017) Science Translational Medicine, 9
Journal article

Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes

Annika Axelsson, T Mahdi, H A Nenonen, Tania Singh, S Hänzelmann, et al.
(2017) Nature Communications, 8 p.15652-15652
Journal article

NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells

Laila R.B. Santos, Carole Muller, Arnaldo H. de Souza, Hilton K. Takahashi, Peter Spégel, et al.
(2017) Molecular Metabolism, 6 p.535-547
Journal article

Transcribing β-cell mitochondria in health and disease

Hindrik Mulder
(2017) Molecular Metabolism, 6 p.1040-1051
Journal article review

Bioenergetic Impairment in Congenital Muscular Dystrophy Type 1A and Leigh Syndrome Muscle Cells

Cibely C Fontes-Oliveira, Maarten Steinz, Peter Schneiderat, Hindrik Mulder, Madeleine Durbeej
(2017) Scientific Reports, 7
Journal article

Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell

Jones K. Ofori, Vishal A. Salunkhe, Annika Bagge, Neelanjan Vishnu, Mototsugu Nagao, et al.
(2017) Scientific Reports, 7
Journal article

HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells

Mahboubeh Daneshpajooh, Karl Bacos, Madhusudhan Bysani, Annika Bagge, Emilia Ottosson Laakso, et al.
(2017) Diabetologia, 60 p.116-125
Journal article

Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss

Nina Geidenstam, Martin Magnusson, Anders P H Danielsson, Robert E Gerszten, Thomas J Wang, et al.
(2017) International Journal of Endocrinology, 2017
Journal article

Cartilage oligomeric matrix protein promotes prostate cancer progression by enhancing invasion and disrupting intracellular calcium homeostasis

Emelie Englund, Giacomo Canesin, Konstantinos S. Papadakos, Neelanjan Vishnu, Emma Persson, et al.
(2017) Oncotarget, 8 p.98298-98311
Journal article

Metabolic coupling in pancreatic beta cells : lipolysis revisited

Hindrik Mulder
(2016) Diabetologia, 59 p.2510-2513
Journal article

Glycogen metabolism in the glucose-sensing and supply-driven β-cell

Lotta E. Andersson, Lisa M. Nicholas, Karin Filipsson, Jiangming Sun, Anya Medina Benavente, et al.
(2016) FEBS Letters, 590 p.4242-4251
Journal article (letter)

Discriminative prediction of A-To-I RNA editing events from DNA sequence

Jiangming Sun, Yang De Marinis, Peter Osmark, Pratibha Singh, Annika Bagge, et al.
(2016) PLoS ONE, 11
Journal article

Precise expression of Fis1 is important for glucose responsiveness of beta cells

Julia Schultz, Rica Waterstradt, Tobias Kantowski, Annekatrin Rickmann, Florian Reinhardt, et al.
(2016) Journal of Endocrinology, 230 p.81-91
Journal article

Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes

Tiinamaija Tuomi, Cecilia L F Nagorny, Pratibha Singh, Hedvig Bennet, Qian Yu, et al.
(2016) Cell Metabolism, 23 p.1067-1077
Journal article

Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer

E Englund, M Bartoschek, B Reitsma, L Jacobsson, A Escudero-Esparza, et al.
(2016) Oncogene, 35 p.5585-5596
Journal article

The Human Diabetes Proteome Project (HDPP) : The 2014 update

D. Schvartz, Patrik Bergsten, K. H. Baek, A. Barba De La Rosa, J. Cantley, et al.
(2015) Translational Proteomics, 8-9 p.1-7
Journal article

Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion

Jelena Stamenkovic, Lotta Andersson, Alice E. Adriaenssens, Annika Bagge, Vladimir Sharoyko, et al.
(2015) Biochemical Journal, 468 p.49-63
Journal article

Characterization of Stimulus-Secretion Coupling in the Human Pancreatic EndoC-βH1 Beta Cell Line.

Lotta Andersson, Berengere Valtat, Annika Bagge, Vladimir Sharoyko, David Nicholls, et al.
(2015) PLoS ONE, 10
Journal article

Calcium Modulation of Exocytosis-Linked Plasma Membrane Potential Oscillations in INS-1 832/13 Cells.

Akos A Gerencser, Hindrik Mulder, David G Nicholls
(2015) Biochemical Journal, 471 p.111-122
Journal article

Unique and Shared Metabolic Regulation in Clonal β-cells and Primary Islets Derived from Rat Revealed by Metabolomics Analysis.

Peter Spégel, Lotta Andersson, Petter Storm, Vladimir Sharoyko, Isabel Göhring, et al.
(2015) Endocrinology, 156 p.1995-2005
Journal article

Season-dependent associations of circadian rhythm-regulating loci (CRY1, CRY2 and MTNR1B) and glucose homeostasis: the GLACIER Study.

Frida Renström, Robert Koivula, Tibor V Varga, Göran Hallmans, Hindrik Mulder, et al.
(2015) Diabetologia, 58 p.997-1005
Journal article

Primary clear cell renal carcinoma cells display minimal mitochondrial respiratory capacity resulting in pronounced sensitivity to glycolytic inhibition by 3-Bromopyruvate.

Helén Nilsson, David Lindgren, A Mandahl Forsberg, Hindrik Mulder, Håkan Axelson, et al.
(2015) Cell Death & Disease, 6
Journal article

Metabolite profile deviations in an oral glucose tolerance test-A comparison between lean and obese individuals.

Nina Geidenstam, Peter Spégel, Hindrik Mulder, Karin Filipsson, Martin Ridderstråle, et al.
(2014) Obesity, 22 p.2388-2395
Journal article

Genotype-based treatment of type 2 diabetes with an α2A-adrenergic receptor antagonist.

Yunzhao Tang, Annika Axelsson, Peter Spégel, Lotta Andersson, Hindrik Mulder, et al.
(2014) Science Translational Medicine, 6 p.139-257
Journal article

Glucagon-Like Peptide 1 Stimulates Insulin Secretion via Inhibiting RhoA/ROCK Signaling and Disassembling Glucotoxicity-Induced Stress Fibers

Xiangchen Kong, Dan Yan, Jiangming Sun, Xuerui Wu, Hindrik Mulder, et al.
(2014) Endocrinology, 155 p.4676-4685
Journal article

Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes.

Vladimir Sharoyko, Mia Abels, Jiangming Sun, Lisa Nicholas, Ines Mollet, et al.
(2014) Human Molecular Genetics, 23 p.5733-5749
Journal article

Chronic high glucose and pyruvate levels differentially affect mitochondrial bioenergetics and fuel-stimulated insulin secretion from clonal INS-1 832/13 cells.

Isabel Göhring, Vladimir Sharoyko, Siri Malmgren, Lotta Andersson, Peter Spégel, et al.
(2014) Journal of Biological Chemistry, 289 p.3786-3798
Journal article

Gastric bypass improves ss-cell function and increases β-cell mass in a porcine model.

Andreas Lindqvist, Peter Spégel, Mikael Ekelund, Eliana Garcia Vaz, Stefan Pierzynowski, et al.
(2014) Diabetes, 63 p.1665-1671
Journal article

Diabetes in Friedreich Ataxia

Miriam Cnop, Hindrik Mulder, Mariana Igoillo-Esteve
(2013) Journal of Neurochemistry, 126 p.94-102
Journal article review

Time-resolved metabolomics analysis of beta-cells implicates the pentose phosphate pathway in the control of insulin release

Peter Spégel, Vladimir Sharoyko, Isabel Göhring, Anders Danielsson, Siri Malmgren, et al.
(2013) Biochemical Journal, 450 p.595-605
Journal article

Coordinate changes in histone modifications, mRNA levels and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity.

Siri Malmgren, Peter Spégel, Anders Danielsson, Cecilia Nagorny, Lotta Andersson, et al.
(2013) Journal of Biological Chemistry, 288 p.11973-11987
Journal article

Effects of ingestion routes on hormonal and metabolic profiles in gastric-bypassed humans

Andreas Lindqvist, Mikael Ekelund, Hindrik Mulder, Peter Spégel, Leif Groop, et al.
(2013) Journal of Clinical Endocrinology and Metabolism, 98 p.856-861
Journal article

Fracture Mechanics of Collagen Fibrils: Influence of Natural Cross-Links

Rene B. Svensson, Hindrik Mulder, Vuokko Kovanen, S. Peter Magnusson
(2013) Biophysical Journal, 104 p.2476-2484
Journal article

The transcriptional co-repressor myeloid translocation gene 16 inhibits glycolysis and stimulates mitochondrial respiration.

Parveen Kumar, Vladimir Sharoyko, Peter Spégel, Urban Gullberg, Hindrik Mulder, et al.
(2013) PLoS ONE, 8
Journal article

Metabolite Profiling Reveals Normal Metabolic Control in Carriers of Mutations in the Glucokinase Gene (MODY2).

Peter Spégel, Ella Ekholm, Tiinamaija Tuomi, Leif Groop, Hindrik Mulder, et al.
(2012) Diabetes
Journal article

Glutamate dehydrogenase, insulin secretion and Type 2 Diabetes. A new means to protect the pancreatic β-cell?

Isabel Göhring, Hindrik Mulder
(2012) Journal of Endocrinology, 212 p.239-242
Journal article

Development of a gas chromatography/mass spectrometry based metabolomics protocol by means of statistical experimental design

Anders Danielsson, Thomas Moritz, Hindrik Mulder, Peter Spégel
(2012) Metabolomics, 8 p.50-63
Journal article

Plasma Membrane Potential Oscillations in Insulin Secreting Ins-1 832/13 Cells do not Require Glycolysis and are not Initiated by Fluctuations in Mitochondrial Bioenergetics.

Isabel Goehring, Akos A Gerencser, Sara Schmidt, Martin D Brand, Hindrik Mulder, et al.
(2012) Journal of Biological Chemistry, 287 p.15706-15717
Journal article

Regulation of core clock genes in human islets.

Jelena Stamenkovic, Anders H Olsson, Cecilia Nagorny, Siri Malmgren, Marloes Dekker Nitert, et al.
(2012) Metabolism, Clinical and Experimental, 61 p.978-985
Journal article

Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal beta-cell lines

Peter Spégel, Siri Malmgren, Vladimir Sharoyko, Philip Newsholme, Thomas Köck, et al.
(2011) Biochemical Journal, 435 p.277-284
Journal article

Matrix Metalloproteinases - keys to healthier blood vessels in diabetes?

Hindrik Mulder
(2011) Journal of Endocrinology, 210 p.1-2
Journal article

Distribution of melatonin receptors in murine pancreatic islets.

Cecilia Nagorny, Ramasri Sathanoori, Ulrikke Voss, Hindrik Mulder, Nils Wierup
(2011) Journal of Pineal Research, 50 p.412-417
Journal article

A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes.

Thomas Koeck, Anders H Olsson, Marloes Dekker Nitert, Vladimir Sharoyko, Claes Ladenvall, et al.
(2011) Cell Metabolism, 13 p.80-91
Journal article

Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells

Ulrika Krus, Olga Kotova, Peter Spégel, Elna Hallgard, Vladimir Sharoyko, et al.
(2010) Biochemical Journal, 429 p.205-213
Journal article

Melatonin effects on insulin secretion and clock genes expression

Jelena Stamenkovic, Cecilia Nagorny, Charlotte Ling, S Albert Salehi, Vladimir Sharoyko, et al.
(2010) Diabetologia, 53 p.93-93
Conference paper: abstract

Metabolomic analysis of a human oral glucose tolerance test reveals fatty acids as reliable indicators of regulated metabolism

Peter Spégel, Anders Danielsson, Karl Bacos, Cecilia Nagorny, Thomas Moritz, et al.
(2010) Metabolomics, 6 p.56-66
Journal article

Pancreatic islets of melatonin receptor knock-out mice

Cecilia Nagorny, Ulrikke Voss, Hedvig Bennet, Jelena Stamenkovic, Ramasri Sathanoori, et al.
(2010) Diabetologia, 53 p.294-294
Conference paper: abstract

Development and optimization of a metabolomic method for analysis of adherent cell cultures

Anders Danielsson, Thomas Moritz, Hindrik Mulder, Peter Spégel
(2010) Analytical Biochemistry, 404 p.30-39
Journal article

A lipotoxicity model in the INS-1 832/13 beta cell line and the epigenetic alterations induced by it

Siri Malmgren, Vladimir Sharoyko, David Nicholls, Cecilia Nagorny, Peter Spégel, et al.
(2010) Diabetologia, 53 p.348-348
Conference paper: abstract

Oxidative phosphorylation-dependent insulin secretion in pancreatic beta cells: new insights by disrupting TFB1M

Thomas Köck, Peter Spégel, Vladimir Sharoyko, Charlotte Ling, Hindrik Mulder
(2010) Diabetologia, 53 p.491-491
Conference paper: abstract

Growth arrest specific protein 6 (gas6) and its receptors expression and signalling in beta cells

Vladimir Sharoyko, Thomas Köck, Carl Ekman, Nils Wierup, Frank Sundler, et al.
(2010) Diabetologia, 53 p.530-530
Conference paper: abstract

The membrane potential response is altered in pancreatic beta cells chronically exposed to high glucose

Isabel Göhring, Thomas Köck, Hindrik Mulder, David Nicholls
(2010) Diabetologia, 53 p.554-554
Conference paper: abstract

Comeback för beta-cellen i diabetespatogenesen.

Hindrik Mulder
(2010) Läkartidningen, 107 p.2796-2800
Journal article

Is shortening of telomeres the missing link between aging and the Type 2 Diabetes epidemic?

Hindrik Mulder
(2010) Aging clinical and experimental research, 2 p.634-636
Journal article

Hyperthyroidism decreases islet pyruvate dehydrogenase kinase 1 (PDHK1) expression and attenuates islet starvation adaptations

M. J. Holness, Hindrik Mulder, Olga Kotova, Ulrika Krus, G. K. Greenwood, et al.
(2009) Diabetologia, 52 p.453-453
Conference paper: abstract

Differences in metabolic regulation between glucose responsive INS-1 832/13 and its glucose non-responsive INS-1 832/2 sister clonal rat beta cell line decides their beta cell functionality

Siri Malmgren, Vladimir Sharoyko, David Nicholls, Hindrik Mulder
(2009) Diabetologia, 52 p.454-454
Conference paper: abstract

Metabolite profiling of clonal (832/13) beta cells after glucose stimulation

Peter Spégel, A. Danielsson, Cecilia Nagorny, Hindrik Mulder
(2009) Diabetologia, 52 p.117-117
Conference paper: abstract

Protein GAS6 and its receptor Axl are expressed and operate in pancreatic beta cells

Vladimir Sharoyko, Carl Ekman, Nils Wierup, Frank Sundler, Björn Dahlbäck, et al.
(2009) Diabetologia, 52 p.448-448
Conference paper: abstract

Mutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretion.

Ruben Smith, Karl Bacos, Valentina Fedele, Denis Soulet, Helena Jones, et al.
(2009) Human Molecular Genetics, 18 p.3942-3954
Journal article

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.

Valeriya Lyssenko, Cecilia Nagorny, Michael R Erdos, Nils Wierup, Anna Jonsson, et al.
(2009) Nature Genetics, 41 p.82-88
Journal article

Mitochondrial dysfunction in pancreatic beta-cells in Type 2 Diabetes.

Hindrik Mulder, Charlotte Ling
(2009) Molecular and Cellular Endocrinology, 297 p.34-40
Journal article

A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis.

Malin Fex, G Haemmerle, Nils Wierup, Marloes Dekker Nitert, M Rehn, et al.
(2009) Diabetologia, 52 p.271-280
Journal article

Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion.

Siri Malmgren, David Nicholls, Jalal Taneera, Karl Bacos, Thomas Koeck, et al.
(2009) Journal of Biological Chemistry, 284 p.32395-32404
Journal article

Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene.

Hindrik Mulder, Cecilia Nagorny, Valeriya Lyssenko, Leif Groop
(2009) Diabetologia, 52 p.1240-1249
Journal article

Disruption of TFB1M impairs insulin secretion in beta cells

Thomas Köck, Marloes Dekker Nitert, A Olsson, Olga Kotova, Jelena Stamenkovic, et al.
(2009) Diabetologia, 52 p.116-116
Conference paper: abstract

Melatonin receptor signalling is involved in insulin secretion in the INS-1 832/13 beta cell line

Cecilia Nagorny, Hindrik Mulder
(2009) Diabetologia, 52 p.401-401
Conference paper: abstract

Metabolomic and proteomic analysis of a clonal insulin-producing beta-cell line (INS-1 832/13).

Celine Fernandez, Ulrika Krus, Elna Hallgard, Peter Spégel, Cecilia Holm, et al.
(2008) Journal of Proteome Research, 7 p.400-411
Journal article

CaV1.2 rather than CaV1.3 is coupled to glucose-stimulated insulin secretion in INS-1 832/13 cells.

Marloes Dekker Nitert, Cecilia Nagorny, Anna Wendt, Lena Eliasson, Hindrik Mulder
(2008) Journal of Molecular Endocrinology, 41 p.1-11
Journal article

A metabolic comparison of glucose-responsive INS-1 832/13 and glucose-nonresponsive INS-1 832/2 cells

Vladimir Sharoyko, Karl Bacos, Avinash Abhyankar, Cecilia Nagorny, Hindrik Mulder, et al.
(2008) Diabetologia, 51 p.203-204
Conference paper: abstract

Islet beta-cell area and hormone expression are unaltered in Huntington's disease.

Karl Bacos, Maria Björkqvist, Åsa Petersén, Lena Luts, Marion Maat-Schieman, et al.
(2008) Histochemistry and Cell Biology, 129 p.623-629
Journal article

Lipases in the pancreatic beta-cell: implications for insulin secretion.

Malin Fex, Hindrik Mulder
(2008) Biochemical Society Transactions, 36 p.885-890
Journal article

Increased metabolism in the R6/2 mouse model of Huntington's disease.

Jorien m van der Burg, Karl Bacos, Nigel I Wood, Andreas Lindqvist, Nils Wierup, et al.
(2008) Neurobiology of Disease, 29 p.41-51
Journal article

Pyruvate dehydrogenase kinase I knock down in INS-1 832/13 Cells enhances insulin secretion and the cellular NADPH/NADP(+) ratio

Olga Kotova, Ulrika Krus, M. C. Sugden, Hindrik Mulder
(2008) Diabetologia, 51 p.201-201
Conference paper: abstract

Rat insulin promoter 2-Cre recombinase mice bred onto a pure C57BL/6J background exhibit unaltered glucose tolerance

Malin Fex, Nils Wierup, Marloes Dekker Nitert, Michael Ristow, Hindrik Mulder
(2007) Journal of Endocrinology, 194 p.551-555
Journal article

Cocaine- and amphetamine-regulated transcript is increased in Huntington disease.

Maria Björkqvist, Blair R Leavitt, Jörgen E Nielsen, Bernhard Landwehrmeyer, Daniel Ecker, et al.
(2007) Movement Disorders, 22 p.1952-1954
Journal article

Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet.

Malin Fex, Marloes Dekker Nitert, Nils Wierup, Frank Sundler, Charlotte Ling, et al.
(2007) Diabetologia, 50 p.74-83
Journal article

Anaplerosis via pyruvate carboxylase is required for the fuel-induced rise in the ATP:ADP ratio in rat pancreatic islets.

Ulrika Krus, Anders Rosengren, F Schuit, Erik Renström, Hindrik Mulder
(2006) Diabetologia, 49 p.1578-1586
Journal article

Cerebrospinal fluid levels of orexin-A are not a clinically useful biomarker for Huntington disease.

Maria Björkqvist, Åsa Petersén, J Nielsen, D Ecker, Hindrik Mulder, et al.
(2006) Clinical Genetics, 70 p.78-79
Journal article (letter)

Progressive alterations in the hypothalamic-pituitary-adrenal axis in the R6/2 transgenic mouse model of Huntington's disease

Maria Björkqvist, Åsa Petersén, Karl Bacos, J Isaacs, Per Norlén, et al.
(2006) Human Molecular Genetics, 15 p.1713-1721
Journal article

CART Regulates Islet Hormone Secretion and Is Expressed in the {beta}-Cells of Type 2 Diabetic Rats.

Nils Wierup, Maria Björkqvist, Michael J Kuhar, Hindrik Mulder, Frank Sundler
(2006) Diabetes, 55 p.305-311
Journal article

{beta}-Cell Lipases and Insulin Secretion.

Malin Fex, Stephanie Lucas, Maria Sörhede Winzell, Bo Ahrén, Cecilia Holm, et al.
(2006) Diabetes, 55 p.24-31
Journal article

The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient {beta}-cell mass and exocytosis.

Maria Björkqvist, Malin Fex, Erik Renström, Nils Wierup, Åsa Petersén, et al.
(2005) Human Molecular Genetics, 14 p.565-574
Journal article

Orexin loss in Huntington's disease.

Åsa Petersén, Joana Gil, Marion L C Maat-Schieman, Maria Björkqvist, Heikki Tanila, et al.
(2005) Human Molecular Genetics, 14 p.39-47
Journal article

Effect of murine strain on metabolic pathways of glucose production after brief or prolonged fasting

SC Burgess, FMH Jeffrey, C Storey, A Milde, N Hausler, et al.
(2005) American Journal of Physiology: Endocrinology and Metabolism, 289 p.53-61
Journal article

Reduction of GnRH and infertility in the R6/2 mouse model of Huntington's disease.

Eugenia Papalexi, Anna Persson, Maria Björkqvist, Åsa Petersén, Ben Woodman, et al.
(2005) European Journal of Neuroscience, 22 p.1541-1546
Journal article

Ghrelin Is Expressed in a Novel Endocrine Cell Type in Developing Rat Islets and Inhibits Insulin Secretion from INS-1 (832/13) Cells.

Nils Wierup, S Yang, R J McEvilly, Hindrik Mulder, Frank Sundler
(2004) Journal of Histochemistry and Cytochemistry, 52 p.301-310
Journal article

Enhanced cAMP/Protein Kinase A signaling determines improved insulin secretion in a clonal insulin-producing {beta}-cell line (INS-1 832/13).

Shumin Yang, Ulrika Krus, Lillian Fagerhus, Lena Stenson, Hans E. Hohmeier, et al.
(2004) Molecular Endocrinology, 18 p.2312-2320
Journal article

Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue

A Boucher, DH Lu, SC Burgess, S Telemaque-Potts, MV Jensen, et al.
(2004) Journal of Biological Chemistry, 279 p.27263-27271
Journal article

Effects of Growth Hormone on the Function of beta-Adrenoceptor Subtypes in Rat Adipocytes.

Shumin Yang, Hindrik Mulder, Cecilia Holm, Steffan Edén
(2004) Obesity Research, 12 p.330-339
Journal article

Cocaine- and Amphetamine-regulated Transcript (CART) Is Expressed in Several Islet Cell Types During Rat Development.

Nils Wierup, M Kuhar, Bengt-Olof Nilsson, Hindrik Mulder, Eva Ekblad, et al.
(2004) Journal of Histochemistry and Cytochemistry, 52 p.169-177
Journal article

Inhibition of lipase activity and lipolysis in rat islets reduces insulin secretion.

Hindrik Mulder, Shumin Yang, Maria Sörhede Winzell, Cecilia Holm, Bo Ahrén
(2004) Diabetes, 53 p.122-128
Journal article

Regulated Exocytosis of GABA-containing Synaptic-like Microvesicles in Pancreatic {beta}-cells.

Matthias Braun, Anna Wendt, Bryndis Birnir, Jonas Broman, Lena Eliasson, et al.
(2004) Journal of General Physiology, 123 p.191-204
Journal article

Hormone-sensitive Lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact.

Malin Fex, Charlotta S. Olofsson, Ulrika Krus, Karl Bacos, Håkan Lindvall, et al.
(2004) Endocrinology, 145 p.3746-3753
Journal article

Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance and deranged glucose morphology.

Linda Härndahl, Nils Wierup, Sven Enerbäck, Hindrik Mulder, Vincent C Manganiello, et al.
(2004) Journal of Biological Chemistry, 279 p.15214-15222
Journal article

Frataxin deficiency in pancreatic islets causes diabetes due to loss of β cell mass

Michael Ristow, Hindrik Mulder, Doreen Pomplun, Tim J. Schulz, Katrin Müller-Schmehl, et al.
(2003) Journal of Clinical Investigation, 112 p.527-534
Journal article

Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass

M Ristow, Hindrik Mulder, D Pomplun, T Schulz, K Muller-Schmehl, et al.
(2003) Journal of Clinical Investigation, 112 p.527-534
Journal article

Hormone-sensitive lipase null mice exhibit signs of impaired insulin sensitivity whereas insulin secretion is intact.

Hindrik Mulder, Maria Sorhede-Winzell, Juan Antonio Contreras, Malin Fex, Kristoffer Strom, et al.
(2003) Journal of Biological Chemistry, 278 p.36380-36388
Journal article

13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)

Danhong Lu, Hindrik Mulder, Piyu Zhao, Shawn C Burgess, Mette V Jensen, et al.
(2002) Proceedings of the National Academy of Sciences, 99 p.2708-2713
Journal article

Unaltered pancreatic islet blood perfusion in islet amyloid polypeptide-deficient mice

PO Carlsson, E Karlsson, Hindrik Mulder, Samuel Gebre-Medhin
(2002) European Journal of Endocrinology, 146 p.107-112
Journal article

The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas.

Nils Wierup, H Svensson, Hindrik Mulder, Frank Sundler
(2002) Regulatory Peptides, 107 p.63-69
Journal article

Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in beta-cells

Hindrik Mulder, Lena Stensson Holst, Håkan Svensson, Eva Degerman, Frank Sundler, et al.
(1999) Diabetes, 48 p.228-232
Journal article

Pituitary adenylate cyclase-activating polypeptide and islet amyloid polypeptide in primary sensory neurons : Functional implications from plasticity in expression on nerve injury and inflammation

Hindrik Mulder, Helen Jongsma, Yanzhen Zhang, Samuel Gebre-Medhin, Frank Sundler, et al.
(1999) Molecular Neurobiology, 19 p.229-253
Journal article review

Pituitary adenylate cyclase-activating peptide is upregulated in sensory neurons by inflammation

Y Zhang, N Danielsen, F Sundler, H Mulder
(1998) NeuroReport, 9 p.2833-2836
Journal article

Protein kinase B is expressed in pancreatic beta cells and activated upon stimulation with insulin-like growth factor I

Lena Stenson, Hindrik Mulder, V Manganiello, Frank Sundler, Bo Ahrén, et al.
(1998) Biochemical and Biophysical Research Communications, 250 p.181-186
Journal article

Islet amyloid polypeptide and calcitonin gene-related peptide expression are upregulated in lumbar dorsal root ganglia after unilateral adjuvant-induced inflammation in the rat paw

H Mulder, Y Zhang, N Danielsen, F Sundler
(1997) Molecular Brain Research, 50 p.35-127
Journal article

Islet amyloid polypeptide and calcitonin gene-related peptide expression are down-regulated in dorsal root ganglia upon sciatic nerve transection

H Mulder, Y Zhang, N Danielsen, F Sundler
(1997) Molecular Brain Research, 47 p.30-322
Journal article

Expression of Islet Amyloid Polypeptide - Localization and regulation in the pancreatic islets, gastrointestinal tract and sensory nervous system.

Hindrik Mulder
(1997)
Dissertation

Hindrik Mulder

Publications