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Harry Björkbacka

Researcher

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Associations of Interleukin-5 With Plaque Development and Cardiovascular Events

Author

  • Anki Knutsson
  • Harry Björkbacka
  • Pontus Dunér
  • Gunnar Engström
  • Christoph J. Binder
  • Anna Hultgårdh Nilsson
  • Jan Nilsson

Summary, in English

Experimental studies have suggested an atheroprotective role of interleukin (IL)-5 through the stimulation of natural immunoglobulin M antibody expression. In the present study we show that there are no associations between baseline levels of IL-5 and risk for development of coronary events or stroke during a 15.7 ± 6.3 years follow-up of 696 subjects randomly sampled from the Malmö Diet and Cancer study. However, presence of a plaque at the carotid bifurcation was associated with lower IL-5 and IL-5 deficiency resulted in increased plaque development at sites of oscillatory blood flow in Apoe−/− mice suggesting a protective role for IL-5 in plaque development.

Department/s

  • Vessel Wall Biology
  • Cardiovascular Research - Cellular Metabolism and Inflammation
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • Cardiovascular Research - Matrix and Inflammation in Atherosclerosis
  • Cardiovascular Research - Epidemiology
  • EpiHealth: Epidemiology for Health
  • Cardiovascular Research - Immunity and Atherosclerosis

Publishing year

2019

Language

English

Pages

891-902

Publication/Series

JACC: Basic to Translational Science

Volume

4

Issue

8

Document type

Journal article

Publisher

Elsevier

Topic

  • Cardiac and Cardiovascular Systems

Keywords

  • atherosclerosis
  • interleukin 5
  • myocardial infarction
  • stroke

Status

Published

Research group

  • Vessel Wall Biology
  • Cardiovascular Research - Cellular Metabolism and Inflammation
  • Cardiovascular Research - Matrix and Inflammation in Atherosclerosis
  • Cardiovascular Research - Epidemiology
  • Cardiovascular Research - Immunity and Atherosclerosis

ISBN/ISSN/Other

  • ISSN: 2452-302X