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ludc webb

Harry Björkbacka

Researcher

ludc webb

High levels of autoantibodies against apoB100 p210 are associated with lower incidence of atrial fibrillation in women

Author

  • Kari Anne Sveen
  • Gustav Smith
  • Harry Björkbacka
  • Marju Orho-Melander
  • Gunnar Engström
  • Isabel Gonçalves
  • Olle Melander
  • Jan Nilsson
  • Eva Bengtsson

Summary, in English

BACKGROUND AND OBJECTIVES: Atrial fibrillation (AF) is associated with inflammation systemically and in the atrial tissue. Oxidized low-density lipoprotein (LDL) is increased in patients with AF and is suggested to be one of the molecules that drives inflammation. Autoantibodies against oxidized LDL and apolipoprotein B100, the protein component of LDL, are linked to atherosclerotic disease. However, whether these autoantibodies are associated with occurrence of AF is not known. We investigated autoantibodies against oxidized apolipoprotein B100 peptides and incidence of AF in a large population-based cohort.

METHODS: IgM and IgG against native and aldehyde-modified apoB100 peptides 210 (p210) and 45 were analyzed by enzyme-linked immunosorbent assay (ELISA) in 5169 individuals from the Malmö Diet and Cancer cohort.

RESULTS: Seven hundred sixty-nine incident AF cases were recorded during a follow-up of 21.3 years. Individuals with high levels of IgM against native p210 at baseline had a lower risk to develop AF; however, the association did not remain after adjustment for age and sex. Women had higher levels of IgM against native p210 than men (0.70 ± 0.22 AU vs. 0.63 ± 0.21 AU, p < 0.001). The association of IgM against native p210 and AF was significantly different between sexes (p for interaction = 0.024), where females with high IgM against p210 had a lower risk for incidence of AF (hazard ratio [95% confidence interval] 4th versus 1st quartile: 0.67 [0.49-0.91]; p = 0.01) after adjusting for risk factors and comorbidities.

CONCLUSION: These findings support an association of humoral autoimmunity with AF.

Department/s

  • WCMM-Wallenberg Centre for Molecular Medicine
  • Heart Failure and Mechanical Support
  • Cardiovascular Epigenetics
  • Cardiology
  • EpiHealth: Epidemiology for Health
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • Molecular Epidemiology and Cardiology
  • Cardiovascular Research - Cellular Metabolism and Inflammation
  • Cardiovascular Research - Immunity and Atherosclerosis
  • Diabetes - Cardiovascular Disease
  • Cardiovascular Research - Epidemiology
  • Department of Clinical Sciences, Malmö
  • Cardiovascular Research - Translational Studies
  • Cardiovascular Research - Hypertension
  • Hepato-Pancreato-Biliary Surgery
  • Surgery (Lund)
  • Cardiovascular Research - Matrix and Inflammation in Atherosclerosis

Publishing year

2021-09-16

Language

English

Publication/Series

Journal of Internal Medicine

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Cardiac and Cardiovascular Systems

Status

Epub

Research group

  • Heart Failure and Mechanical Support
  • Cardiovascular Epigenetics
  • Molecular Epidemiology and Cardiology
  • Cardiovascular Research - Cellular Metabolism and Inflammation
  • Cardiovascular Research - Immunity and Atherosclerosis
  • Diabetes - Cardiovascular Disease
  • Cardiovascular Research - Epidemiology
  • Cardiovascular Research - Translational Studies
  • Cardiovascular Research - Hypertension
  • Hepato-Pancreato-Biliary Surgery
  • Cardiovascular Research - Matrix and Inflammation in Atherosclerosis

ISBN/ISSN/Other

  • ISSN: 1365-2796