Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

ludc webb

Harry Björkbacka

Researcher

ludc webb

Oxidized lipoprotein autoimmunity: an emerging drug target in cardiovascular disease

Author

  • Jan Nilsson
  • Gunilla Nordin Fredrikson
  • Kuang-Yuh Chyu
  • Prediman K. Shah
  • Harry Björkbacka

Summary, in English

Oxidative modification of low-density lipoprotein (LDL) in the arterial wall is believed to be one of the most important mechanisms involved in the development of atherosclerosis. It is well established that oxidized (Ox)-LDL uptake is responsible for the formation of macrophage foam cells, one of the most characteristic hallmarks of the atherosclerotic plaque, and that the proinflammatory and cytotoxic effects of Ox-LDL play an important role in vascular inflammation and lesion development. More recently, it has become apparent that Ox-LDL is also recognized by the immune system, thus resulting in innate and adaptive immune reactions modulating both Ox-LDL clearance and the vascular inflammatory response. The finding that some of these immune responses have a protective effect against plaque development has focused attention on the potential to develop novel therapies for the prevention and treatment of cardiovascular disease based on the selective activation of this protective immunity by vaccines, or mimicking them directly by using Ox-LDL-specific antibodies.

Department/s

  • Cardiovascular Research - Immunity and Atherosclerosis

Publishing year

2006

Language

English

Pages

321-330

Publication/Series

Future Lipidology

Volume

1

Issue

3

Document type

Journal article review

Publisher

Future Medicine Ltd.

Topic

  • Cardiac and Cardiovascular Systems

Keywords

  • antigen-presenting cells
  • antibodies
  • atherosclerosis
  • heat shock
  • immunomodulation
  • proteins
  • T cells
  • oxidized LDL

Status

Published

Research group

  • Cardiovascular Research - Immunity and Atherosclerosis

ISBN/ISSN/Other

  • ISSN: 1746-0875