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ludc webb

Harry Björkbacka

Researcher

ludc webb

Low Levels of CD4+CD28null T Cells at Baseline Are Associated With First-Time Coronary Events in a Prospective Population-Based Case-Control Cohort

Author

  • Lukas Tomas
  • Eva Bengtsson
  • Linda Andersson
  • Wiaam Badn
  • Christoffer Tengryd
  • Ana Persson
  • Andreas Edsfeldt
  • Peter M Nilsson
  • Alexandru Schiopu
  • Jan Nilsson
  • Isabel Gonçalves
  • Harry Björkbacka

Summary, in English

OBJECTIVE: CD4+CD28null T cells have been shown to be associated with recurrent coronary events and suggested as potential biomarker and therapeutic target. It is unknown whether CD4+CD28null T cells associate with first-time cardiovascular events. We examined CD4+CD28null T cells in a prospective population-based cohort and in patients with advanced atherosclerosis. Approach and Results: CD4+CD28null T cells were quantified in 272 individuals experiencing a first-time coronary event during up to 17 years of follow-up and 272 age- and sex-matched controls in a case-control study, nested within the population-based Malmö Diet and Cancer study. The highest tertile of CD4+CD28null T cells was associated with a lower incidence of first-time coronary events compared with the lowest tertile (odds ratio, 0.48 [95% CI, 0.29-0.79], P=0.004) when adjusting for Framingham risk factors. This association remained significant for events recorded after >9 years of follow-up, when most coronary events occurred, but not during the first 9 years of follow-up, despite similar odds ratio. Additionally, we analyzed CD4+CD28null T cells in 201 patients with advanced atherosclerosis undergoing carotid endarterectomy. The adjusted hazard ratio for cardiovascular events in patients with advanced atherosclerosis was 2.11 (95% CI, 1.10-4.05, P=0.024), comparing the highest with the lowest CD4+CD28null T-cell tertile.

CONCLUSIONS: Our findings reveal complex associations between CD4+CD28null T cells and cardiovascular disease. Although we confirm the reported positive associations with an adverse prognosis in patients with already established disease, the opposite associations with first-time coronary events in the population-based cohort may limit the clinical use of CD4+CD28null T cells.

Department/s

  • Cardiovascular Research - Cellular Metabolism and Inflammation
  • Cardiovascular Research - Immunity and Atherosclerosis
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • Cardiovascular Research - Matrix and Inflammation in Atherosclerosis
  • Cardiovascular Research - Translational Studies
  • Internal Medicine - Epidemiology
  • EpiHealth: Epidemiology for Health
  • Hepato-Pancreato-Biliary Surgery
  • Surgery (Lund)

Publishing year

2020-02

Language

English

Pages

426-436

Publication/Series

Arteriosclerosis, Thrombosis, and Vascular Biology

Volume

40

Issue

2

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Cardiac and Cardiovascular Systems

Keywords

  • Atherosclerosis/blood
  • CD28 Antigens/immunology
  • CD4-Positive T-Lymphocytes/immunology
  • Case-Control Studies
  • Coronary Artery Disease/blood
  • Coronary Vessels/diagnostic imaging
  • Female
  • Flow Cytometry
  • Follow-Up Studies
  • Forecasting
  • Humans
  • Incidence
  • Lymphocyte Count
  • Male
  • Middle Aged
  • Population Surveillance
  • Prospective Studies
  • Sweden/epidemiology
  • T-Lymphocytes/immunology

Status

Published

Research group

  • Cardiovascular Research - Cellular Metabolism and Inflammation
  • Cardiovascular Research - Immunity and Atherosclerosis
  • Cardiovascular Research - Matrix and Inflammation in Atherosclerosis
  • Cardiovascular Research - Translational Studies
  • Internal Medicine - Epidemiology
  • Hepato-Pancreato-Biliary Surgery

ISBN/ISSN/Other

  • ISSN: 1524-4636