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ludc webb

Harry Björkbacka

Researcher

ludc webb

Inflammation and immunity in diabetic vascular complications.

Author

  • Jan Nilsson
  • Eva Bengtsson
  • Gunilla Nordin Fredrikson
  • Harry Björkbacka

Summary, in English

PURPOSE OF REVIEW: Diabetes is associated with an increased risk for cardiovascular disease. The purpose of this review is to discuss possible mechanisms through which diabetes can contribute to a more aggressive atherosclerotic disease process with a particular focus on the role of innate and adaptive immunity. RECENT FINDINGS: The observation that adaptive immune responses to oxidized LDL modulate atherosclerotic plaque development has led to development of pilot vaccines that inhibit atherosclerosis in experimental animals. Recent studies have shown that similar immune responses operate against self-antigens modified by glycation in diabetes. Diabetes has also been shown to activate proinflammatory innate immune receptors and intracellular oxidative stress. SUMMARY: There are many similarities between the autoimmune responses against oxidized LDL and proteins modified by glycation. The role of autoimmune responses against modified self-antigens in the development of diabetic vascular complications represents a relatively unexplored concept that potentially could provide significant new mechanistic insight into the underlying disease process and identify novel targets for intervention.

Department/s

  • Cardiovascular Research - Immunity and Atherosclerosis

Publishing year

2008

Language

English

Pages

519-524

Publication/Series

Current Opinion in Lipidology

Volume

19

Issue

5

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Cardiovascular Research - Immunity and Atherosclerosis

ISBN/ISSN/Other

  • ISSN: 1473-6535