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ludc webb

Harry Björkbacka

Researcher

ludc webb

IL-1R and MyD88 signalling in CD4+ T cells promote Th17 immunity and atherosclerosis

Author

  • Daniel Engelbertsen
  • Sara Rattik
  • Maria Wigren
  • Jenifer Vallejo
  • Goran Marinkovic
  • Alexandru Schiopu
  • Harry Björkbacka
  • Jan Nilsson
  • Eva Bengtsson

Summary, in English

The role of CD4+ T cells in atherosclerosis has been shown to be dependent on cytokine cues that regulate lineage commitment into mature T helper sub-sets. In this study, we tested the roles of IL-1R1 and MyD88 signalling in CD4+ T cells in atherosclerosis. Methods and results We transferred apoe-/-myd88\+/\+ or apoe-/-myd88-/- CD4+ T cells to T-A nd B-cell-deficient rag1-/-apoe-/- mice fed high fat diet. Mice given apoe-/-myd88-/- CD4+ T cells exhibited reduced atherosclerosis compared with mice given apoe-/-myd88\+/\+ CD4+ T cells. CD4+ T cells from apoe-/-myd88-/- produced less IL-17 but similar levels of IFN-c. Treatment of human CD4+ T cells with a MyD88 inhibitor inhibited IL-17 secretion in vitro. Transfer of il1r1-/- CD4+ T cells recapitulated the phenotype seen by transfer of myd88-/- CD4+ T cells with reduced lesion development and a reduction in Th17 and IL-17 production compared with wild type CD4+ T cell recipients. Relative collagen content of lesions was reduced in mice receiving il1r1-/- CD4+ T cells. Conclusion We demonstrate that both IL1R and MyD88 signalling in CD4+ T cells promote Th17 immunity, plaque growth and may regulate plaque collagen levels.

Department/s

  • EXODIAB: Excellence of Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health
  • Cardiovascular Research - Immunity and Atherosclerosis
  • Rausing laboratory of Lund - Tumor section
  • Cardiovascular Research - Cellular Metabolism and Inflammation
  • Surgery (Lund)
  • Department Office of Clinical Sciences, Lund

Publishing year

2018-01-01

Language

English

Pages

180-187

Publication/Series

Cardiovascular Research

Volume

114

Issue

1

Document type

Journal article

Publisher

Oxford University Press

Topic

  • Cardiac and Cardiovascular Systems

Keywords

  • Atherosclerosis
  • IL-1
  • MyD88
  • T cells
  • Th17

Status

Published

Research group

  • Cardiovascular Research - Immunity and Atherosclerosis
  • Rausing laboratory of Lund - Tumor section
  • Cardiovascular Research - Cellular Metabolism and Inflammation

ISBN/ISSN/Other

  • ISSN: 0008-6363