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Gustav Smith

Associate professor

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Mortality risks associated with sibling heart failure

Author

  • Magnus P. Lindgren
  • Jianguang Ji
  • J. Gustav Smith
  • Jan Sundquist
  • Kristina Sundquist
  • Bengt Zöller

Summary, in English

Background The mortality in individuals with a family history of heart failure (HF) has not been determined. This nationwide sib-pair study aimed to determine mortality in individuals with a sibling affected with HF. Methods Sib-pairs were linked using the Swedish Multi-Generation Register, the Hospital Discharge Register and the Cause of Death Register for the period 1987–2012. Families with cardiomyopathy or congenital heart disease were excluded. Mortality hazard ratios (HRs) were calculated for siblings of individuals who had been diagnosed with HF compared with siblings of individuals unaffected by HF as the reference group. Similar analyses were made for spouses. HRs were determined for overall mortality, cardiovascular mortality, and death of unknown cause. Results Among siblings, the adjusted HR for overall mortality was 1.21 (95% CI 1.18–1.25). This risk remained (HR = 1.19, 95% CI 1.15–1.23) also among subjects without HF themselves. The adjusted HRs for cardiovascular mortality and death of unknown cause were 1.39 (95% CI 1.32–1.45) and 1.58 (95% CI 1.29–1.95), respectively. The mortality risk associations with spousal HF were all minimal, with an overall mortality HR of 1.02 (1.01–1.02). Early sibling age of onset of HF

Department/s

  • Family medicine, cardiovascular medicine and genetics
  • Family Medicine and Clinical Epidemiology
  • Heart Failure and Mechanical Support
  • Cardiovascular Epigenetics
  • Cardiology
  • EpiHealth: Epidemiology for Health
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • Molecular Epidemiology and Cardiology
  • Family Medicine, Cardiovascular Epidemiology and Lifestyle

Publishing year

2020-05-15

Language

English

Pages

114-118

Publication/Series

International Journal of Cardiology

Volume

307

Document type

Journal article

Publisher

Elsevier

Topic

  • Cardiac and Cardiovascular Systems
  • Public Health, Global Health, Social Medicine and Epidemiology
  • Medical Genetics

Keywords

  • Heart failure
  • Family history
  • Mortality
  • Genetics
  • Epidemiology

Status

Published

Research group

  • Family medicine, cardiovascular medicine and genetics
  • Family Medicine and Clinical Epidemiology
  • Heart Failure and Mechanical Support
  • Cardiovascular Epigenetics
  • Molecular Epidemiology and Cardiology
  • Family Medicine, Cardiovascular Epidemiology and Lifestyle

ISBN/ISSN/Other

  • ISSN: 0167-5273