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Gustav Smith

Associate professor

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Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'

Author

  • Nils Landegren
  • Lindsey B. Rosen
  • Eva Freyhult
  • Daniel Eriksson
  • Tove Fall
  • Gustav Smith
  • Elise M.N. Ferre
  • Petter Brodin
  • Donald Sharon
  • Michael Snyder
  • Michail Lionakis
  • Mark Anderson
  • Olle Kämpe

Summary, in English

The AIRE gene plays a key role in the development of central immune tolerance by promoting thymic presentation of tissue-specific molecules. Patients with AIRE-deficiency develop multiple autoimmune manifestations and display autoantibodies against the affected tissues. In 2016 it was reported that: i) the spectrum of autoantibodies in patients with AIRE-deficiency is much broader than previously appreciated; ii) neutralizing autoantibodies to type I interferons (IFNs) could provide protection against type 1 diabetes in these patients (Meyer et al., 2016). We attempted to replicate these new findings using a similar experimental approach in an independent patient cohort, and found no evidence for either conclusion.

Department/s

  • Heart Failure and Mechanical Support
  • Cardiovascular Epigenetics
  • EpiHealth: Epidemiology for Health
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • Molecular Epidemiology and Cardiology
  • WCMM-Wallenberg Centre for Molecular Medicine

Publishing year

2019-06-27

Language

English

Publication/Series

eLife

Volume

8

Document type

Journal article

Publisher

eLife Sciences Publications

Topic

  • Endocrinology and Diabetes
  • Immunology in the medical area

Keywords

  • APS1/APECED
  • autoantibody
  • autoantigen
  • human
  • human biology
  • immune tolerance
  • immunology
  • inflammation
  • medicine
  • type 1 diabetes

Status

Published

Research group

  • Heart Failure and Mechanical Support
  • Cardiovascular Epigenetics
  • Molecular Epidemiology and Cardiology

ISBN/ISSN/Other

  • ISSN: 2050-084X