The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Default user image.

Gustav Smith

Associate professor

Default user image.

Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis.

Author

  • Gustav Smith
  • Kevin Luk
  • Christina-Alexandra Schulz
  • James C Engert
  • Ron Do
  • George Hindy
  • Gull Rukh
  • Line Dufresne
  • Peter Almgren
  • David S Owens
  • Tamara B Harris
  • Gina M Peloso
  • Kathleen F Kerr
  • Quenna Wong
  • Albert V Smith
  • Matthew J Budoff
  • Jerome I Rotter
  • L Adrienne Cupples
  • Stephen Rich
  • Sekar Kathiresan
  • Marju Orho-Melander
  • Vilmundur Gudnason
  • Christopher J O'Donnell
  • Wendy S Post
  • George Thanassoulis

Summary, in English

Plasma low-density lipoprotein cholesterol (LDL-C) has been associated with aortic stenosis in observational studies; however, randomized trials with cholesterol-lowering therapies in individuals with established valve disease have failed to demonstrate reduced disease progression.

Department/s

  • Cardiology
  • Diabetes - Cardiovascular Disease
  • Genomics, Diabetes and Endocrinology
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2014

Language

English

Pages

1764-1771

Publication/Series

JAMA: The Journal of the American Medical Association

Volume

312

Issue

17

Document type

Journal article

Publisher

American Medical Association

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Diabetes - Cardiovascular Disease
  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 1538-3598