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Gabriella Gremsperger

Gabriella Gremsperger

Biomedical analyst

Gabriella Gremsperger

Association of IRS1 genetic variants with glucose control and insulin resistance in type 2 diabetic patients from Bosnia and Herzegovina

Author

  • Lejla Mahmutovic
  • Tamer Bego
  • Maria Sterner
  • Gabriella Gremsperger
  • Emma Ahlqvist
  • Zelija Velija Asimi
  • Besim Prnjavorac
  • Nour Hamad
  • Adlija Causevic
  • Leif Groop
  • Sabina Semiz

Summary, in English


Previous studies reported conflicting results regarding association of insulin receptor substrate 1 (IRS1) gene variation with type 2 diabetes (T2D) and insulin resistance (IR) in different ethnic groups. We examined the association of rs7578326, rs2943641, and rs4675095 in the IRS1 gene with T2D and related traits in a population from Bosnia and Herzegovina, which is one of the European countries with the highest T2D prevalence of 12.5%. Our study included 390 T2D patients and 252 control subjects. Biochemical parameters, including fasting glucose (FG), fasting insulin (FI), homeostasis model assessment insulin resistance index (HOMA-IR), and HbA
1c
were measured in all participants. Genotyping analysis was performed by Mass Array Sequenom iPlex platform. Our results demonstrated that rs7578326 and rs4675095 variants were associated with increased FG levels. The rs7578326 was also associated with higher FI, HOMA-IR (B = 0.08, 95% CI [0.01, 0.15], p
add
= 0.025; B = 0.079, 95% CI [0.006, 0.150], p
add
= 0.033, respectively) in T2D, and with HbA
1c
(B = 0.034, 95% CI [0.003, 0.065], p
dom
= 0.035) in non-drug-treated T2D. In contrast, rs2943641 C allele was associated with lower FG levels in control subjects (B = -0.17, 95% CI [-0.03, -0.002], p
add
= 0.030) and HbA
1c
(B = 0.03, 95% CI [0.002, 0.06], p
dom
= 0.040) in non-drug-treated T2D. We report the association between common variants in IRS1 gene with insulin resistance, glucose, and HbA
1c
levels in Bosnia and Herzegovina's population.

Department/s

  • Genomics, Diabetes and Endocrinology
  • EXODIAB: Excellence in Diabetes Research in Sweden

Publishing year

2019

Language

English

Publication/Series

Drug Metabolism and Personalized Therapy

Volume

34

Issue

1

Document type

Journal article

Publisher

De Gruyter

Topic

  • Endocrinology and Diabetes

Keywords

  • fasting glucose
  • HbA
  • HOMA-IR
  • insulin resistance
  • IRS1
  • single nucleotide polymorphism

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 2363-8907