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Filip Ottosson

Research student

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Postprandial Levels of Branch Chained and Aromatic Amino Acids Associate with Fasting Glycaemia

Author

  • Filip Ottosson
  • Ulrika Ericson
  • Peter Almgren
  • Jeanette Nilsson
  • Martin Magnusson
  • Celine Fernandez
  • Olle Melander

Summary, in English

High fasting plasma concentrations of isoleucine, phenylalanine, and tyrosine have been associated with increased risk of hyperglycaemia and incidence of type 2 diabetes. Whether these associations are diet or metabolism driven is unknown. We examined how the dietary protein source affects the postprandial circulating profile of these three diabetes associated amino acids (DMAAs) and tested whether the postprandial DMAA profiles are associated with fasting glycaemia. We used a crossover design with twenty-one healthy individuals and four different isocaloric test meals, containing proteins from different dietary sources (dairy, fish, meat, and plants). Analysis of the postprandial DMAAs concentrations was performed using targeted mass spectrometry. A DMAA score was defined as the sum of all the three amino acid concentrations. The postprandial area under the curve (AUC) of all the three amino acids and the DMAA score was significantly greater after intake of the meal with dairy protein compared to intake of the three other meals. The postprandial AUC for the DMAA score and all the three amino acids strongly associated with fasting glucose level and insulin resistance. This indicates the importance of the postprandial kinetics and metabolism of DMAAs in understanding the overall association between DMAAs and glycaemia.

Department/s

  • Cardiovascular Research - Hypertension
  • Diabetes - Cardiovascular Disease
  • Genomics, Diabetes and Endocrinology
  • Department Office of Experimental Medical Science
  • Department of Clinical Sciences, Malmö
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2016

Language

English

Publication/Series

Journal of Amino Acids

Volume

2016

Document type

Journal article

Publisher

Hindawi Limited

Topic

  • Nutrition and Dietetics

Status

Published

Project

  • The use of Genomics and Proteomics for the Detection and Prevention of Cardiometabolic Disease

Research group

  • Cardiovascular Research - Hypertension
  • Diabetes - Cardiovascular Disease
  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 2090-0104