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Falastin Salami

Research project participant

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Beta cell function in participants with single or multiple islet autoantibodies at baseline in the TEDDY Family Prevention Study : TEFA

Author

  • Maria Månsson Martinez
  • Falastin Salami
  • Helena Elding Larsson
  • Jorma Toppari
  • Åke Lernmark
  • Jukka Kero
  • Riitta Veijola
  • Jaakko J Koskenniemi
  • Päivi Tossavainen
  • Markus Lundgren
  • Henrik Borg
  • Anastasia Katsarou
  • Marlena Maziarz
  • Carina Törn

Summary, in English

Aim: The aim of the present study was to assess beta cell function based on an oral glucose tolerance test (OGTT) in participants with single islet autoantibody or an intravenous glucose tolerance test (IvGTT) in participants with multiple islet autoantibodies. Materials and methods: Healthy participants in Sweden and Finland, between 2 and 49.99 years of age previously identified as positive for a single (n = 30) autoantibody to either insulin, glutamic acid decarboxylase, islet antigen-2, zinc transporter 8 or islet cell antibodies or multiple autoantibodies (n = 46), were included. Participants positive for a single autoantibody underwent a 6-point OGTT while participants positive for multiple autoantibodies underwent an IvGTT. Glucose, insulin and C-peptide were measured from OGTT and IvGTT samples. Results: All participants positive for a single autoantibody had a normal glucose tolerance test with 120 minutes glucose below 7.70 mmol/L and HbA1c values within the normal range (<42 mmol/mol). Insulin responses to the glucose challenge on OGTT ranged between 13.0 and 143 mIU/L after 120 minutes with C-peptide values between 0.74 and 4.60 nmol/L. In Swedish participants, the first-phase insulin response (FPIR) on IvGTT was lower in those positive for three or more autoantibodies (n = 13; median 83.0 mIU/L; range 20.0-343) compared to those with two autoantibodies (n = 15; median 146 mIU/L; range 19.0-545; P =.0330). Conclusion: Participants positive for a single autoantibody appeared to have a normal beta cell function. Participants positive for three or more autoantibodies had a lower FPIR as compared to participants with two autoantibodies, supporting the view that their beta cell function had deteriorated.

Department/s

  • Diabetes and Celiac Unit
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • Paediatric Endocrinology
  • Diabetic Complications

Publishing year

2021-04

Language

English

Publication/Series

Endocrinology, Diabetes & Metabolism

Volume

4

Issue

2

Document type

Journal article

Publisher

John Wiley and Sons

Topic

  • Endocrinology and Diabetes

Keywords

  • HbA1c
  • intravenous glucose tolerance test
  • oral glucose tolerance test

Status

Published

Research group

  • Diabetes and Celiac Unit
  • Paediatric Endocrinology
  • Diabetic Complications

ISBN/ISSN/Other

  • ISSN: 2398-9238