LUDC/DPLU Diabetes Research day
13:15-14:15 Key note speaker: professor Melina Claussnitzer, the Broad Institute and Harvard, Boston, US
"Variant-to-Function (V2F) Studies in the Context of Type 2 Diabetes and its Comorbidities"
Abstract: Large-scale human genetic studies have succeeded in identifying more than 60,000 associations between genetic loci and human diseases and traits, including many hundreds for Type 2 Diabetes and its comorbidities. However, these GWAS loci have only rarely been resolved into causal variants or mechanisms due to several challenges. The vast majority of loci involve non-coding variants that likely act through regulatory changes; over 80% of GWAS loci contain no protein-altering common variants, even when considering all variants in linkage disequilibrium (LD) at r2≥0.8, making it difficult to pinpoint the causal variants, regulatory circuits, relevant cell types and tissues, key developmental stages, and affected cellular functions. We have pioneered a five-step model to convert genetic associations into functions, which involves (1) identifying the causal variant, (2) pinpointing which gene regulators are impacted by the variant, (3) finding the downstream target gene(s), (4) determining the relevant tissue and cell types, and (5) identifying the cellular and organismal pathways and functions altered by the variant. In this talk, I will provide examples of such Variant-to-Function (V2F) studies in the context of T2D and its comorbidities. I will further introduce novel technologies that we develop to accelerate and facilitate such V2F efforts.
14:15-14:45 Rashmi Prasad, Genomics, Diabetes and Endrcrinology, LUDC
"Fetal programming and type 2 diabetes"
14:45-15:00 PhD student speech of the year I
Hugo Pomares Millan, Genetic and molecular epdiemiology, LUDC
"Environmental risk assessment and cardiometabolic traits"
15:30-16:30 The Leif C. Groop award for outstanding diabetes research (formerly known as the DPLU/LUDC Nordic Prize for an outstanding your diabetes investigator)
The stipend has been made possible by a generous donation from Novo Nordisk Scandinavia. Its puropse is professional improvement. It should be used for future education, research or the like, and be of value for patients, academic research and health care.
Prize lecture title: tba
16:30-16:45 PhD student talk of the year II
Franiziska Kopietz, Proteinphosforylation, LUDC
"Regulation of AMPK and lipid storage by insulin"
16:45-17:00 Announcement of the DPLU PhD student prize followed by prize lecture
17:00-17:30 João Paulo da Cunha, Molecular Metabolism, LUDC, SE
"Use of insulin-secreting beta-like cells generated from iPS cells procured from T2D risk carriers"
17:30 Concluding remarks
17:45 Mingle (at CRC, floor 11) and dinner at CRC restaurant (notification necessary)