LUDC/DPLU Diabetes Research Day
12:00 Registration and lunch
Ulrika Krus, steering committee of DPLU
13:15 Key Note Speaker
Professor John A Todd, Oxford University, UK
"Genes to clinic in type 1 Diabetes"
John Todd FRS, FMedSci, FRCP Hons, PhD is Professor of Precision Medicine at the University of Oxford (until recently Professor of Medical Genetics at the University of Cambridge), Director of the JDRF/Wellcome Trust Diabetes and Inflammation Laboratory (DIL) in the University’s Wellcome Centre for Human Genetics, and a Senior Investigator of the National Institute for Health Research. His PhD was in Biochemistry at the University of Cambridge. Todd researches type 1 diabetes (T1D) genetics and disease mechanisms with an aim of clinical intervention. Previously, Todd was Professor of Human Genetics and a Wellcome Trust Principal Research Fellow at the University of Oxford. Todd helped pioneer genome-wide genetic studies, first in mice and then in humans. He then went on to study the associations between mapped genomic disease-associated regions and phenotypes by founding and deploying the Cambridge BioResource. His research in genetics and diabetes has received several awards and prizes. In the latest phase of his research, to translate basic genetic and immunological knowledge to treatment and prevention, the DIL has now completed its first two mechanistic, statistically adaptive, drug dose-finding studies in T1D patients. This design and analyses have revealed several previously unknown effects of interleukin-2 (IL-2) on the human immune system, providing key information on the future possibility of using subcutaneous administration of ultra-low doses of IL-2 to preserve pancreatic islet beta-cell function to treat and prevent T1D. In Oxford the DIL is launching a programme to investigate which T1D risk regions affect beta-cell function and fragility. We are applying the latest single-cell, mass spectrometry methods, bioinformatics and statistical methods.
Todd has supervised 31 PhD students with three in progress. h-index 94, total citations over 38,000.
14:15 João Duarte, Lund University
"Brain energy metabolism in type 2 diabetes"
14:45 PhD student speech of the year I, Ingrid Yao Mattisson
"Elevated markers of death receptor-activated apoptosis are associated with increased risk for development of diabetes and cardiovascular disease"
15:30 Hjelt stipend lecture, Emma Ahlqvist
The stipend is generously donated by Ulf Andersson for outstanding achievements in research granted by The Bo and Kerstin Hjelt Diabetes Foundation
"Novel subgroups of adult-onset diabetes sharpen genetic associations and improve prediction of outcome"
16:00 PhD student speech of the year II, Louise Brunkwall
"Human gut microbiota in Malmö Offspring Study"
16:15 Announcement of the DPLU PhD student prize and prize lecture
16:30 The Leif C Groop award for outstanding diabetes research (formerly known as the DPLU/LUDC Nordic Prize for an outstanding young diabetes investigator)
The stipend has been made possible by a generous donation from NovoNordisk Scandinavia. Its purpose is professional improvement. It should be used for future education, research or the like, and be of value for patients, academic research and health care.
Recipient: Jorge Lira Ruas, KI, Stockholm, SE
"Understanding the impact of exercise on muscle, metabolism and mental health"
17:30 Concluding remarks
17:45 Mingel and dinner at CRC