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Extremism can be useful

The large-scale genome-wide association studies significantly contributed to the identification of a substantial number of genetic variants associated with complex metabolic conditions such as obesity and diabetes. Nevertheless, given that many of the genomic loci reside in the non-coding regions it is very difficult to design appropriate biological experiments for functional validation. Recent evidence from a number of successful examples from genotype-based recall demonstrated not only validity of the genomic discoveries and but also illuminated novel biological mechanisms through detailed targeted physiological investigations in these extreme individuals. How to unmask the most impactful categories of phenotypic and genotypic extremes will be discussed during our joint Genomics, diabetes and endocrinology-group at LUDC/UiB/FIMM meeting “Extremism can be useful” at CRC in Malmö, CRC.

In order to secure a sandwich for lunch, please register to Ulrika.


Wednesday March 20th 2019

08:30-09:00 Registration, coffee/tea and fruit

09:00-09:45 Current and future perspective in diabetes research
Leif Groop, Lund University, Sweden and FIMM, Finland

09:45-10:45 Industry- and clinic perspective on current and future challenges in diabetes research

09:45-10:15 Allan Vaag, AstraZeneca, Sweden
Research needs fro the clinical trials

10:15-10:30 Peter Nilsson, Lund University and Internal medicine, SUS Malmö
Needs in the clinical diabetes research

10:30-10:45 Nael Shaat, Lund University and endocrinological clinic, SUS Malmö
Needs in the clinical diabetes research

10:45-11:00 Coffee and tea

11:00-11:40 Human Knockouts - Illuminating examples of recruitment by genotype studies?

11:00-11:20 Mikko Lehtovirta, FIMM, Finland
Human knockouts - Zinc transporter gene variant as an example of recrutiment by genotype

11:20-11:40 Rashmi Prasad, LUDC, Sweden
Extremes in temporal relationships: Parent-of-origin effects and diabetes risk

11:40-13:00 Lunch and networking

13:00-14:00 Novel approaches to clinical trails

13:00-13:30 Valeriya Lyssenko, LUDC, Sweden and University of Bergen, Norway
                     Bjørn Olav Åsvold, NTNU, Trondheim, Norway

Extremes by genetic risk score and phenotypes

13:30-14:00 Claes Wollheim, LUDC, Sweden and University of Geneva, Switzerland
Discovery of a diabetes executer gene: VDAC1 inhibitors in the prevention of T2D

14:00-14:15 Coffe and tea

Hop topics

14:15-15:15 Pancreatic cells in focus

14:15-14:45 Simona Chera, University of Bergen, Norway
Alpha cells in focus

14:45-15:15 Nils Wierup, LUDC, Sweden
Extreme single cell sequencing

15:15-16:15 Key note lecture
Kay Prüfer, Max-Planck Institute, Leipzig, Germany

Phenotypes from the past

16:15-16:30 Coffee and tea

16:30-17:30 Extreme muscle, obesity and diets

16:30-16:50 Ola Hansson, LUDC, Sweden
Extreme muscle strength

16:50-17:10 Johan Fernø, University of Bergen, Norway
Extreme obesity

17:10-17:30 Simon Dankel, University of Bergen, Norway
Extreme diets

18:00- Social activities (invitees)


Thursday March 21st

08:30-09:00 Caffee/tea and fruit will be served

09:00-10:00 Diabetes subtypes

09:00-09:30 Dina Mansour-Aly, LUDC, Sweden
Extremely Novel Diabetes Subtypes

09:30-10:00 Olof Asplund, LUDC, Sweden
Diabetes classification tools for caregivers and researchers

10:00-11:00 Extreme genes and metabolic memory

10:00-10:30 Karianne Fjeld, University of Bergen, Norway
CEL: an extremely polymorphic gene involved in pancreatic disease

10:30-11:00 Yang De Marinis, LUDC, Sweden
Exocrine extremism and metabolic memory

11:00-12:00 Hunting for Xtremes and children studies

11:00-11:30 Stefan Johansson, University of Bergen, Norway

Title I: Hunting for MODY-Xtremes

Title II: Genetics of BMI in infancy and early childhood - an extreme end of the BMI-spectrum

11:30-12:00 Luiza Ghila, University of Bergen, Norway
iPS-derived pancreatic cells - extreme fiction or treatment reality?

12:00-12:15  Ola Hansson, Valeriya Lyssenko and Johan Fernø
Closing remarks and future perspective

12:15 Lunch and departure



20 March 2019 09:00 to 21 March 2019 14:00
Agardh lecture hall, CRC, Jan Waldenstöms gata 35, SUS Malmö

About the event

20 March 2019 09:00 to 21 March 2019 14:00
Agardh lecture hall, CRC, Jan Waldenstöms gata 35, SUS Malmö

Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00