Skeletal muscle is an insulin-responsive organ and the primary site for post-prandial glucose disposal. Skeletal muscle insulin resistance, leading to a reduction in insulin-stimulated glucose disposal, is often an early defect contributing to the development of type 2 diabetes.
microRNAs, are short RNA molecules which are able to post-transcriptionally modulate the abundance of several different mRNAs dependent on the presence of complimentary sequences in the 3’ terminal tails. Recent efforts have been focused on understanding the role of microRNAs in tissue function and in different disease states. In this lecture I will discuss our recent results regarding miRNAs important for human skeletal muscle metabolism and identification of miRNAs altered in the context of type 2 diabetes or in response exercise intervention. The role of exosomally carried miRNAs will also be discussed.