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Eva Degerman

Eva Degerman

Research team manager

Eva Degerman

Rye bran alkylresorcinols suppress adipocyte lipolysis and hormone-sensitive lipase activity

Author

  • Ulrika Axling
  • Estera Dey
  • Cecilia Holm
  • Eva Degerman

Summary, in English

The effects of alkylresorcinols (ARs) isolated from rye bran on adipocyte lipolysis, hormone-sensitive lipase activity and phosphorylation and on phosphorylation of protein kinase A substrates were studied. Preincubation with ARs for 18 h suppressed catecholamine-stimulated lipolysis in 3T3-L1 adipocytes. Furthermore, phosphorylation of hormone-sensitive lipase (HSL), a key lipase responsible for stimulated lipolysis, and phosphorylation of protein kinase A substrates, were diminished after preincubation with ARs, whereas HSL protein expression was unaltered. ARs were also shown to inhibit HSL activity in an in vitro assay.

Department/s

  • Molecular Endocrinology
  • Pure and Applied Biochemistry
  • Insulin Signal Transduction
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2011

Language

English

Pages

290-293

Publication/Series

Molecular Nutrition and Food Research

Volume

55

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Nutrition and Dietetics

Keywords

  • Adipose tissue
  • Alkylresorcinols
  • Lipolysis
  • Type 2 diabetes
  • Whole
  • grain

Status

Published

Project

  • ANTIDIABETIC FOOD CENTRE

Research group

  • Molecular Endocrinology
  • Insulin Signal Transduction

ISBN/ISSN/Other

  • ISSN: 1613-4133