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Eva Degerman

Eva Degerman

Professor

Eva Degerman

Long-term regulation of cyclic nucleotide phosphodiesterase type 3B and 4 in 3T3-L1 adipocytes.

Author

  • Alina Oknianska
  • Emilia Zmuda-Trzebiatowska
  • Vincent Manganiello
  • Eva Degerman

Summary, in English

Phosphodiesterase 3B (PDE3B), is known to play an important role in acute insulin and cAMP-mediated regulation of lipid metabolism, and PDE4 are the main PDE types expressed in adipocytes. Here, we show that members of all PDE4 isoforms are expressed in 3T3-L1 and primary mouse adipocytes. Long-term treatment of 3T3-L1 adipocytes with insulin induced up-regulation of PDE3B and PDE4D in a phosphatidylinositol 3-kinase-dependent manner whereas long-term treatment with P-adrenergic agonists induced down-regulation of PDE3B and up-regulation of PDE4D. Thus, PDE3B and PDE4D can be added to the list of genes regulated by insulin and cAMP-increasing hormones. Altered expression of PDE3B and PDE4D in response to long-term treatment with insulin and catecholamines may contribute to altered regulation of metabolism in diabetes. (c) 2006 Elsevier Inc. All rights reserved.

Department/s

  • Insulin Signal Transduction

Publishing year

2007

Language

English

Pages

1080-1085

Publication/Series

Biochemical and Biophysical Research Communications

Volume

353

Issue

4

Document type

Journal article

Publisher

Elsevier

Topic

  • Biological Sciences

Keywords

  • phosphodiesterase 3B
  • phosphodiesterase 4
  • adipocyte
  • insulin
  • isoproterenol

Status

Published

Research group

  • Insulin Signal Transduction

ISBN/ISSN/Other

  • ISSN: 1090-2104