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Eva Degerman

Eva Degerman

Professor

Eva Degerman

Expression of insulin signalling components in the sensory epithelium of the human saccule.

Author

  • Eva Degerman
  • Uwe Rauch
  • Sven Lindberg
  • Per Caye-Thomasen
  • Anna Hultgårdh
  • Måns Magnusson

Summary, in English

Several studies have demonstrated a link between diabetes and the dysfunction of the inner ear. Few studies, however, have reported the signalling mechanisms involved in metabolic control in human inner ear cells. Knowledge of the expression and role of the insulin receptor and downstream signalling components in the inner ear is sparce. Our immunohistochemistry approach has shown that the insulin receptor, insulin receptor substrate 1 (IRS1), protein kinase B (PKB) and insulin-sensitive glucose transporter (GLUT4) are expressed in the sensory epithelium of the human saccule, which also exhibits expression of a calcium-sensitive cAMP/cGMP phosphodiesterase 1C (PDE1C) and the vasopressin type 2 receptor. IRS1 and PDE1C are selectively expressed in sensory epithelial hair cells, whereas the other components are expressed in sensory epithelial supporting cells or in both cell types, as judged from co-expression or non-co-expression with glial fibrillary acidic protein, a marker for supporting cells. Furthermore, IRS1 appears to be localized in association with sensory nerves, whereas GLUT4 is expressed in the peri-nuclear area of stromal cells, as is the case for aquaporin 2. Thus, the insulin receptor, insulin signalling components and selected cAMP signalling components are expressed in the human saccule. In addition to well-known mechanisms of diabetes complications, such as neuropathy and vascular lesions, the expression of these proteins in the saccule could have a role in the observed link between diabetes and balance/hearing disorders.

Department/s

  • Insulin Signal Transduction
  • Vessel Wall Biology
  • Otorhinolaryngology (Lund)
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2013

Language

English

Pages

469-478

Publication/Series

Cell and Tissue Research

Volume

352

Issue

3

Document type

Journal article

Publisher

Springer

Topic

  • Cell Biology

Status

Published

Research group

  • Insulin Signal Transduction
  • Vessel Wall Biology

ISBN/ISSN/Other

  • ISSN: 1432-0878