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Rye bran alkylresorcinols suppress adipocyte lipolysis and hormone-sensitive lipase activity

Author:
  • Ulrika Axling
  • Estera Dey
  • Cecilia Holm
  • Eva Degerman
Publishing year: 2011
Language: English
Pages: 290-293
Publication/Series: Molecular Nutrition and Food Research
Volume: 55
Document type: Journal article
Publisher: John Wiley & Sons

Abstract english

The effects of alkylresorcinols (ARs) isolated from rye bran on adipocyte lipolysis, hormone-sensitive lipase activity and phosphorylation and on phosphorylation of protein kinase A substrates were studied. Preincubation with ARs for 18 h suppressed catecholamine-stimulated lipolysis in 3T3-L1 adipocytes. Furthermore, phosphorylation of hormone-sensitive lipase (HSL), a key lipase responsible for stimulated lipolysis, and phosphorylation of protein kinase A substrates, were diminished after preincubation with ARs, whereas HSL protein expression was unaltered. ARs were also shown to inhibit HSL activity in an in vitro assay.

Keywords

  • Nutrition and Dietetics
  • Adipose tissue
  • Alkylresorcinols
  • Lipolysis
  • Type 2 diabetes
  • Whole
  • grain

Other

Published
  • Molecular Endocrinology
  • Insulin Signal Transduction
  • ISSN: 1613-4133
Eva Degerman
E-mail: eva [dot] degerman [at] med [dot] lu [dot] se

Professor

Insulin Signal Transduction

+46 46 222 85 83

+46 70 885 83 62

BMC C1121b

66

Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00