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Salicylamide and salicylglycine oxidovanadium complexes with insulin-mimetic properties.

Author:
  • Jessica Nilsson
  • Albert A Shteinman
  • Eva Degerman
  • Eva A Enyedy
  • Tamás Kiss
  • Ulrich Behrens
  • Dieter Rehder
  • Ebbe Nordlander
Publishing year: 2011
Language: English
Pages: 1795-1800
Publication/Series: Journal of Inorganic Biochemistry
Volume: 105
Document type: Journal article
Publisher: Elsevier

Abstract english

Reaction of N-(2-hydroxybenzyl)-N-(2-picolyl) glycine (H(2)papy) with VOSO(4) in water gives the oxidovanadium(V) oxido-bridged dimer [{(papy)(VO)}(2) μ-O)] (1). Similarly, reaction of N-(2-hydroxybenzyl) glycine (H(2)glysal) with VOSO(4) gives [(glysal)VO(H(2)O)] (2) and reaction of salicylamide (Hsalam) with VOSO(4) in methanol gives [(salam)(2)VO] (3). The crystal structure of the oxido-bridged complex 1 is reported. The insulin-mimetic activity of all three complexes was evaluated with respect to their ability to phosphorylate protein kinase B (PKB). The speciations of complexes 1 and 2 were studied over the pH range 2-10. Complex 1 shows greater stability over the whole pH range but only 2 and 3 exhibit an insulin-mimetic effect.

Keywords

  • Biochemistry and Molecular Biology

Other

Published
  • Insulin Signal Transduction
  • ISSN: 1873-3344
Eva Degerman
E-mail: eva [dot] degerman [at] med [dot] lu [dot] se

Professor

Insulin Signal Transduction

+46 46 222 85 83

+46 70 885 83 62

BMC C1121b

66

Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00