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Superantigen activates the gp130 receptor on adipocytes resulting in altered adipocyte metabolism.

  • Elin Banke
  • Karin Rödström
  • Mikael Ekelund
  • Jonathan Dalla-Riva
  • Jens Lagerstedt
  • Staffan Nilsson
  • Eva Degerman
  • Karin Lindkvist
  • Bo Nilson
Publishing year: 2014
Language: English
Pages: 831-840
Publication/Series: Metabolism, Clinical and Experimental
Volume: 63
Issue: 6
Document type: Journal article
Publisher: Elsevier

Abstract english

The bacteria Staphylococcus aureus is part of the normal bacterial flora and produces a repertoire of enterotoxins which can cause food poisoning and toxic shock and might contribute to the pathogenesis of inflammatory diseases. These enterotoxins directly cross-link the T cell receptor with MHC class II, activating large amounts of T cells and are therefore called superantigens. It was recently discovered that the superantigen SEA binds to the cytokine receptor gp130. As obesity and type 2 diabetes are highly associated with inflammation of the adipose tissue and gp130 has been shown to play an important role in adipocytes, we wanted to investigate the effect of SEA on adipocyte signaling and function.


  • Cell and Molecular Biology


  • Insulin Signal Transduction
  • Medical Structural Biology
  • Medical Protein Science
  • ISSN: 1532-8600
Eva Degerman
E-mail: eva [dot] degerman [at] med [dot] lu [dot] se


Insulin Signal Transduction

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